3D打印非共面模板引导125Ⅰ粒子组织间近距离治疗盆腔肿瘤个体化设计  

3D-printing non-coplanar template assisted 125I seed implantation for pelvic tumor： individual template design method

作　　者：孙海涛[1] 姚丽红[1] 王俊杰[1] 周付根[2] 姜玉良[1] 吉喆[1] 刘博[2] 郭福新[1] 彭冉[1] 范京红[1] 

机构地区：[1]北京大学第三医院肿瘤放疗科,100191 [2]北京航空航天大学图像处理中心

出　　处：《中华放射医学与防护杂志》2017年第7期485-489,共5页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的 对比3D打印非共面模板引导125Ⅰ粒子植入治疗盆腔肿瘤的术前计划与术后计划的剂量学结果，探索盆腔部肿瘤放射性粒子植入治疗用个体化模板设计方法的可行性、精确性。方法 2015年12月至2016年12月于本院接受3D打印非共面模板引导粒子植入的盆腔肿瘤患者51例，处方110~160 Gy，设计制作3D打印非共面模板51块，对比术前、术后剂量学参数，包括D90、最小周边剂量（mPD）、V100、V150、V200、适形指数（CI）、靶区外体积指数（EI）、均匀性指数（HI）。结果 为51例患者设计、制作的51块导板术中就位良好，与术前计划相比，术后D90、V100、V150、V200、CI、EI及HI差异无统计学意义（P〉 0.05）；mPD高于术前，差异有统计学意义（t=-2.96，P〈0.05）。结论 术后验证的主要剂量学指标较好地达到了术前计划要求，有良好的治疗精确性，能满足临床需求。Objective To compare the dosimetric data between preoperative plans and postoperative verification in computed tomography （CT）-guided and 3D-printing non-coplanar template-assisted 125Ⅰ seed implantation for pelvic tumor, and to explore the feasibility and accuracy of the personalized template designmethod. Methods A total of 51 patients registered from Dec 2015 to Dec 2016 who were applied with 3D-printing guided template assisted radioactive seed implantations in the hospital were included in this study.A prescribed dose of 110-160 Gy was adopted. 3D-printing templates were designed and produced for 51 cases. The dosimetric parameters： D90, minimum peripheral dose （mPD）, V100, V150, V200, conformal index （CI）, external index （EI）, and homogeneity index （HI） were compared between pre-and post-plans. Results 51 cases＇ templates were in place well during the operations. Compared with the preoperative planning, the postoperative D90, V100, V150, V200, CI, EI and HI differences had no statistical difference （P〉0.05）; mPD is larger than before （t=-2.96,P〈0.05）. Conclusions The main dosimetric parameters of postoperative verification were consistent well with the preoperative planning and have good accuracy, which could meet the clinical requirements.

关 键 词：3D打印 放射性粒子植入 个体化非共面模板 剂量学 盆腔肿瘤 

分 类 号：R730.55[医药卫生—肿瘤]