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机构地区:[1]广东省惠州市第六人民医院,广东惠州516211
出 处:《中国医学创新》2017年第21期120-122,共3页Medical Innovation of China
摘 要:目的:探讨鼠神经生长因子联合甲钴胺治疗视神经挫伤的临床效果和安全性。方法:选取2015年10月-2017年3月在本院治疗的64例视神经挫伤患者,采用随机数字表法分为观察组和对照组,每组32例。对照组在常规治疗的基础上仅给予甲钴胺治疗,观察组在常规治疗的基础上给予鼠神经生长因子联合甲钴胺治疗,比较两组患者的治疗效果、视野缺损程度和不良事件发生情况。结果:治疗1、2个疗程后,观察组的总有效率均显著高于对照组,视野缺损程度低于对照组,差异均有统计学意义(P<0.05),且两组患者均未出现严重的不良事件。结论:鼠神经生长因子联合甲钴胺治疗视神经挫伤具有较好的临床效果,可显著改善患者的视力恢复情况,减轻视野缺损程度,且安全性较好,可考虑在临床推广应用。Objective: To discuss clinical efficacy and safety of mouse nerve growth factor combined with Mecobalamin for patients with optic nerve contusion.Method: From October 2015 to March 2017, 64 patients with optic nerve contusion treated in our hospital were selected, and they were divided into observation group and control group according to the random number table method, 32 cases in each group.The control group received Mecobalamin treatment on the basis of routine treatment, the observation group received mouse nerve growth factor combined with Meeobalamin treatment on the basis of routine treatment.The therapeutic effect, degree of visual field defects and adverse events of two groups were compared.Result: The total effective rate of the observation group after 1 course and 2 courses of treatment were higher than those of the control group, the degree of visual field defect in observation group was lower than that of the control group, the differences were statistically significant (P〈0.05), and patients both of two groups had no serious adverse events.Conclusion: Mouse nerve growth factor combined with Methyleobalamin in treatment of optic nerve contusion has good clinical effect, which can improve the patient's visual acuity significantly, reduce the extent of visual defect, has well security, can be considered apply in clinical.
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