抑郁症病人认知功能损害特点及其机制  

CHARACTERISTICS AND MECHANISM OF COGNITIVE IMPAIRMENT IN PATIENTS WITH DEPRESSION

作　　者：赵蕾[1] 范勇[1] 董玉霞[1] 孟祥军[1] 

机构地区：[1]青岛市精神卫生中心精神科,山东青岛266034

出　　处：《齐鲁医学杂志》2017年第2期208-209,213,共3页Medical Journal of Qilu

摘　　要：目的分析抑郁症病人认知功能损害的特点、患病机制以及相关影响因素,以改善抑郁症病人的认知功能。方法选取2015年1—12月我院收治的54例抑郁症病人为研究组,另选取54例同期健康查体者为对照组,比较两组病人的认知功能测试结果。结果治疗前,两组威斯康星卡片分类测验总测试次数、持续错误数、随机错误数、随机正确数、操作时间、思考时间及连续测验时间比较,差异有显著性(t=9.34~23.56,P<0.05)。研究组病人治疗后以上指标与治疗前比较,差异有显著性(t=8.20~29.97,P<0.05)。结论抑郁症会给病人的认知功能造成一定损害,经治疗后随着临床症状的改善,认知功能会逐渐好转,但很难在短时间内恢复正常。Objective To analyze the characteristics, mechanism, and related influencing factors for cognitive impairment in patients with depression and to improve the cognitive function of patients with depression. Methods A total of 54 patients with depression who were admitted to our hospital from January to December, 2015 were enrolled as the study group. Ano ther 54 healthy subjects in the same period were selected as the control group. The cognitive function test results were compared be tweeu the two groups. Results Before treatment, there were significant differences in the total number of tests, the number of consecutive errors, the number of random errors, the number of random correct results, operating time, thinking time, and con tinuous test time in Wisconsin Card Sorting Test between the two groups （t=9.34--23.56,P〈0.05）. The study group had significant improvements in the above indices after treatment （t=8.20--29.97,P〈0.05）. Conclusion Depression will cause some damage to the cognitive function of patients. After treatment, the cognitive function will gradually improve with the improvement in clinical symptoms, but it is difficult to return to normal in a short time.

关 键 词：抑郁症 认知障碍 心理学试验 

分 类 号：R749.41[医药卫生—神经病学与精神病学]