CD163^+肿瘤相关巨噬细胞在常见上皮性皮肤肿瘤中的分布  

Detect of CD163^+ tumor associated macrophages in common skin epithelial tumors

作　　者：周文明[1,2] 张伟[1] 申小平[1] 刘志[1] 李世军[1] 陆洪光[1] 

机构地区：[1]贵州医科大学附属医院皮肤科,贵州贵阳550004 [2]贵州省铜仁市人民医院,贵州铜仁554300

出　　处：《中国麻风皮肤病杂志》2017年第7期385-389,共5页China Journal of Leprosy and Skin Diseases

基　　金：贵州医科大学学科建设经费资助(编号:0215025100104)

摘　　要：目的:检测CD163+肿瘤相关巨噬细胞在皮肤鳞状细胞癌、基底细胞癌、鲍温病、日光性角化病中的分布。方法:采用免疫组织化学法(Max Vision法)检测CD163标记的肿瘤相关巨噬细胞在正常皮肤、鳞状细胞癌、基底细胞癌、鲍温病、日光性角化病中的分布。结果:每高倍镜视野下正常皮肤、鲍温病、日光性角化病真皮浅层中CD163+巨噬细胞个数为(9.5000±1.71594)、(43.9200±9.98716)和(49.4000±8.73830)个;基底细胞癌肿瘤间质中为(42.1724 1±11.73234),鳞状细胞癌的肿瘤间质中及肿瘤实质内为(65.8421±14.05649)。结论:CD163+肿瘤相关巨噬细胞可能与皮肤上皮性肿瘤的发生、发展相关。Objective： To detect the distribution of CD163~＋ tumor associated macrophage in skin squamous cell carcinoma,basal cell carcinoma,Bowen ＇s disease and actinic keratosis. Methods： The distribution of CD163~＋ tumor associated macrophages under in the normal skin,skin squamous cell carcinoma,basal cell carcinoma,Bowen＇s disease and actinic keratosis were detected by the immunohistochemitry method（ Max Vision）. Results： The number of CD163~＋ tumor associated macrophage in the upper dermis of the normal skin,Bowen＇s disease and actinic keratosis were（ 9. 5000 ± 1. 71594）,（ 43. 9200 ± 9. 98716） and（ 49. 4000 ±8.73830） respectively and 42. 17241 ± 11. 73234 in the tumor stroma of basal cell carcinoma,65. 8421 ±14.05649 in the tumor stroma and parenchyma of the skin squamous cell carcinoma. Conclusion： The CD163~＋ tumor associated macrophages may play an important role in the occurrence and development of the common skin epithelial tumors.

关 键 词：肿瘤相关巨噬细胞 皮肤鳞状细胞癌 基底细胞癌 鲍温病 日光性角化病 CD163 

分 类 号：R739.5[医药卫生—肿瘤]