齐拉西酮对首发精神分裂症患者认知功能影响的Meta分析  

The Effect of Ziprasidone and Risperidone for the Cognitive Disorder in Patients with the Tirst-episode Schizophrenia:A Meta-Analysis

作　　者：孙志刚[1] 李素水[1] 王灵君[1] 宋丽华[1] 张红梅[1] 薛曼[1] 

机构地区：[1]河北省石家庄市第八医院,050081

出　　处：《中国健康心理学杂志》2017年第7期964-969,共6页China Journal of Health Psychology

基　　金：河北省高层次人才资助项目(编号:A2016002087);河北省科技计划(编号:152777223);石家庄市科技计划(编号:131460693)

摘　　要：目的:综合评价利培酮和齐拉西酮对首发精神分裂症患者认知功能的影响。方法:以"利培酮"、"维思通"、"齐拉西酮"、"齐哌西酮"、"噻帕西酮"、"首发"、"认知"为中文检索词,以"risperidone"、"ziprasidone"、"cognitive disorder"为英文检索词在中国知网、万方、维普和Cochrance Library、Pubmed等数据库中进行检索,检索2010年以后发表的文献,纳入齐拉西酮与利培酮对比治疗首发精神分裂症患者认知功能的随机对照试验(RCT),对纳入的RCT进行质量评价,采用RevMan 5.0软件对威斯康星卡片分类测验(WCST)中正确应答数、完成分类数、持续性错误数、错误应答数、总应答数进行Meta分析。结果:共纳入6个RCT。Meta分析显示,(1)正确应答数:齐拉西酮组高于利培酮组,差异有统计学意义[MD=3.29,95%CI(1.59,4.99),P<0.001];(2)完成分类数:齐拉西酮组高于利培酮组,差异有统计学意义[MD=0.62,95%CI(0.01,1.23),P<0.001];(3)持续性错误数:齐拉西酮组与利培酮组间的差异无统计学意义[MD=-2.17,95%CI(-4.46,0.61),P=0.13];(4)错误应答数:齐拉西酮组与利培酮组间的差异无统计学意义[MD=-0.66,95%CI(-8.30,6.98),P=0.87];(5)总应答数:齐拉西酮组高于利培酮组,差异有统计学意义[MD=5.77,95%CI(4.12,7.43),P<0.001]。结论:齐拉西酮与利培酮治疗首发精神分裂症的认知功能均有一定的疗效;其中正确应答数、完成分类数和总应答数,齐拉西酮组显著优于利培酮组。因此,齐拉西酮对首发精神分裂症的认知功能更有效。Objective：To evaluate the effect of risperidone and ziprasidone on cognitive function in patients with first- episode schizophrenia. Methods： Literatures were identified using China National Knowledge Infrastructure （CNKI） （2010- 2016）, Wanfang database （ 2010 - 2016）, Weipu database （ 2010 - 2016 ）, Cochrance library （ 2010 - 2016） and Pubmed （ 2010 - 2016 ） with ＂ risperidone risperdal＂ ,＂ ziprasidone＂ ,＂ zepiperidone ＂, ＂ ziprasidone ＂ ,＂ first＂ , ＂cognitive＂ as the Chinese search terms and risperidone＂, ＂ziprasidone＂, ＂cognitive disorder＇as the English search terms.Only articles in which searched randomized controlled trials（RCTs）comparing the effect of Ziprasidone and Risperidone for the cognitive disorder in patients with the first--episode Schizophrenia. The randomized con- trolled trials was evaluated, the number of correct answers, number of completed categories, number of persistent errors,number of error responses,total number of responses in the Wisconsin Card Sorting Test（WCST）were extrac- ted and meta--analyses were conducted with RevMan 5.0 software.Results： Six RCTs were included.The results of meta-analyses showed that： （1）Compared with the risperidone groups, there was more correct answers in the ziprasidone groups（P〈0.001）.（2）Compared with the risperidone groups, there was more completed categories in the ziprasidone groups（P〈0.001）.（3）There was no significant difference in the number of persistent errors between the ziprasidone and the risperidone groups（P〉0.05）.（4）There was no significant difference in the number of error re- sponses between the ziprasidone and the risperidone groups （P 〉 0.05）. （5） Compared with the risperidone groups, there was more correct answers in the ziprasidone groups（P 〈0.001）.（6）Compared with the risperidone groups, there was more responses in the ziprasidone groups （P 〈 0.001）.Conclusion： Ziprasidone and risperidone are both specif

关 键 词：齐拉西酮 利培酮 首发精神分裂症 认知障碍 荟萃分析 

分 类 号：R749.053[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]