腹腔镜与开腹宫颈癌根治术对患者血清IL-4,IL-10,TNF-α及IFN-γ水平的影响  

Comparison of Effects of Laparoscopic and Open Radical Hysterectomy on Serum IL-4,IL-10,TNF-α and IFN-γ Levels of Patients with Cervical Cancer

作　　者：韩敏[1] 李晓[1] 孙华[1] 赵菊惠 侯敏敏[2] 

机构地区：[1]四川省绵阳市中心医院妇产科,四川绵阳621000 [2]四川大学华西第二医院妇产科,四川成都621000

出　　处：《现代生物医学进展》2017年第22期4334-4337,共4页Progress in Modern Biomedicine

基　　金：四川省自然科学基金项目(2012C218)

摘　　要：目的:探讨腹腔镜与开腹宫颈癌根治术对患者血清白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-a)、γ-干扰素(IFN-γ)水平的影响。方法:选取2014年3月至2016年9月在我院接受治疗的64例宫颈癌患者作为研究对象,通过随机方式分为腹腔组和开腹组。比较两组患者的手术时间、术中出血量、术后通气时间、治疗前后血清IL-4、IL-10、TNF-a、IFN-r水平的变化。结果:腹腔组患者的术中出血量和术后通气时间明显低于或短于开腹组(P<0.05),而两组患者的手术时间比较差异无统计学意义(P>0.05)。术前,两组患者的血清IL-4、IL-10、TNF-α及IFN-γ水平比较差异均无统计学意义(P>0.05);术中,腹腔组的血清IL-4水平明显低于开腹组(P<0.05),其余三组指标水平与开腹组比较差异无统计学意义(P>0.05);术后1天和7天,腹腔组患者的血清IL-4、IL-10、TNF-α及IFN-γ水平均明显低于开腹组(P<0.05)。结论:腹腔镜宫颈癌根治术在术中失血量更少,安全性更高,且对于患者术后的IL-4、IL-10、TNF-α和IFN-γ水平抑制效果更加明显,利于患者的术后恢复。Objective： To compare of the effects of laparoscopic and open radical hysterectomy on the serum Interleukin-4（IL-4）, interleukin-10 （IL-10）, tumor Necrosis Factor-α （TNF-α） and lnterferon-γ （IFN-γ） levels of Patients with Cervical Cancer. Methods： 64 patients of cervical cancer who were treated from March 2014 to September 2016 in our hospital were selected as research objects. The patients were randomly divided into the abdominal cavity group and open group. The operative time, blood loss,postoperative ventilation time and the levels of IL-4, IL-10, TNF-a and IFN-γin serum before and after treatment were compared between the two groups. Results： The intraoperative blood loss and postoperative ventilation time were significantly lower or shorter in the abdominal cavity group than in the open group （P〈0.05）. There was no statistically significant difference in the operation time between the two groups （P〉0.05）. There were no significant differences in the levels of serum 1L-4, IL-10, TNF-α and IFN-γ between the two groups before operation（P〉0.05）; The serum IL-4 level was significantly lower than that of the open group during the operation （P〈0.05）. There was no significant difference in the other three index between the other three groups and the laparotomy group （P〉0.05）. The serum levels of IL-4, IL-10, TNF-α and IFN-~/in the abdominal cavity group were significantly lower than those of the laparotomy group on the Ist and 7th day after operation（P〈0.05）. Conclusion： Laparoscopic radical mastectomy in cervical intraoperative less blood loss and more secure. The effect of IL-4. IL-10 TNF-α and IFN-γn the postoperative patients was more obvious.Conducive to the recovery of patients after surgery.

关 键 词：宫颈癌 腹腔镜 白细胞介素-4 白细胞介素-10 肿瘤坏死因子-α Γ干扰素 

分 类 号：R737.33[医药卫生—肿瘤]