手术治疗无淋巴结转移食管癌患者的预后分析  

作　　者：汪亮[1] 蔡磊[1] 陈倩[1] 蒋友华[1] 

机构地区：[1]浙江省肿瘤医院胸部肿瘤外科,310022

出　　处：《浙江临床医学》2017年第8期1407-1408,1411,共3页Zhejiang Clinical Medical Journal

摘　　要：目的 研究无淋巴结转移的胸段食管鳞状细胞癌手术患者的临床病理特征及预后影响因素.方法 回顾性分析2007年1月至2014年12月间751例接受食管癌根治手术并且病理确诊为无淋巴结转移胸段食管鳞癌患者的临床病理资料,采用Kaplan-Meier方法和多因素Cox比例风险模型研究此类食管癌患者预后的独立影响因素.结果 本组食管癌患者术后1、3和5年总体生存率分别为91.47%、72.33%和65.12%.单因素生存分析显示,性别、肿瘤直径、浸润深度、脉管瘤栓、神经侵犯、大体分型、淋巴结总数、吸烟史和酗酒史对食管癌预后有影响（P〈0.05）,多因素cox回归分析结果显示肿瘤直径、浸润深度、脉管瘤栓、淋巴结总数和酗酒史是影响本组食管癌患者预后的独立因素.结论 对于无淋巴结转移的食管鳞癌患者,肿瘤直径、浸润深度、脉管瘤栓、淋巴结总数和酗酒史是影响预后的重要因素.Objective To investigate the clinicopathological characteristics and prognosis in surgical patients with lymph node-negative esophageal cancer. Methods Between January 2007 and December 2014,clinicopathological characteristics of 751 patients with node-negative esophageal cancer who underwent radical esophagectomy in Zhejiang Cancer Hospital were retrospectively analyzed. Kaplan-Meier curves and Multivariate Cox proportional hazards models were used to evaluate the association between survival and each clinicopathological factor. Results The 1-,3-,and 5-year overall survival rates for patients with node-negative esophageal cancer were 91.47%,72.33% and 65.12% respectively. The univariate analysis showed that gender,tumor size,depth of invasion,vascular invasion,nerve invasion,macroscopic type,operation excision lymph node number,smoking history,and alcoholism had significant effects on the survival（P〈0.05）. Multivariate analysis for these factors showed that tumor size,depth of invasion vascular invasion,operation excision lymph node number,and alcoholism were independent prognostic survival factors. Conclusion Tumor size,depth of invasion,vascular invasion,operation excision lymph node number,and alcoholism are important prognostic factors of patients with node-negative esophageal cancer.

关 键 词：食管癌 食管癌根治术 预后 

分 类 号：R735.1[医药卫生—肿瘤]