血小板计数与急性梗阻性化脓性胆管炎相关性分析  

Correlation Analysis between Platelet Count and Acute Obstructive Suppurative Cholangitis

作　　者：杨艳[1] 周中银[1] 陈璐[1] 

机构地区：[1]武汉大学人民医院消化内科,430060

出　　处：《医学研究杂志》2017年第8期87-90,共4页Journal of Medical Research

基　　金：湖北省科技厅基金资助项目(2013BKB013)

摘　　要：目的探讨血小板计数与急性梗阻性化脓性胆管炎(AOSC)有无相关性及可能性影响因素。方法回顾性分析笔者医院2012年10月~2015年10月收治的57例急性梗阻性化脓性胆管炎(acute obstructive suppurative cholangitis,AOSC)患者(AOSC组)及同时期收治的60例普通急性胆管炎患者(普通急性胆管炎组)的临床资料。分析血小板计数减少(<100×109/L)与AOSC之间是否存在相关性,AOSC组患者再根据血小板计数减少分为实验组和对照组,将患者的年龄、性别、既往有无胆管手术史、入院后6h内白细胞(WBC)计数、中性粒细胞百分比(NEU%)、降钙素原(PCT)等6个因素作为考察对象,比较分析两组患者的临床资料,以探讨AOSC患者血小板计数减少的可能性影响因素。结果血小板计数减少在AOSC组和普通胆管炎组中比较差异有统计学意义(P=0.01);实验组与对照组两组相关因素分析比较,血NEU%、PCT两个因素比较差异有统计学意义(P<0.05),年龄、性别、既往有无胆管手术史、入院后6h内白细胞(WBC)计数比较,差异无统计学意义(P>0.05);行多因素Logistic回归分析发现,AOSC时血NEU%、PCT是血小板减少的独立预测因素。结论 AOSC与血小板计数减少存在相关性,且可用来评价急性胆管炎的严重程度,AOSC时血NEU%、PCT是血小板减少的独立预测因素。Objective To investigate platelet counts and acute obstructive suppurative cholangitis correlation analysis and possible influential factors. Methods Data of 117 patients from October 2012 to October 2015 treated in our hospital, of whom 57 with acute ob- structive suppurative cholangitis and 60 with common acute cholangitis were analyzed retrospectively to explore whether there was a correla- tion between thrombocytopenia （100 × 109/L） and AOSC, then experimental and control groups were established according to thrombocy- topenia in the AOSC patients. The patient＇s age, sex, previous biliary surgery, white blood cells（WBC） count after admission within 6h, the percentage of neutrophils （ NEU% ） , ealcitonin （PCT） were retrospectively analyzed to further explore the influence factors of throm- bocytopenia in AOSC patients. Results By comparison with the common acute cholangitis group, thrombocytopenia in AOSC group had obvious difference （ P = 0. 01 ）. In experimental group, NEU% , PCT had statistical difference compared with those in control group （ P 〈 0.05） , and the patient＇s age, sex, previous biliary surgery, white blood cells（WBC） after admission within 6h count had no statistical significance. The logistic multivariate regression analysis showed that, NEU% , PCT were the independent predictors. Conclusion Cor- related with AOSC, thrombocytopenia can be valued as indicators of the severity of acute cholangitis. In AOSC patients, NEU% , PCT were independent predictors of thrombocytopenia.

关 键 词：血小板计数 胆管炎 相关性 分析 

分 类 号：R575.7[医药卫生—消化系统]