胃乃安胶囊联合心理干预对晚期胃癌化疗患者免疫功能及生活质量的影响  

Effect of gastric capsule combined with psychological intervention on immune function and quality of life in patients with advanced gastric cancer

作　　者：高学群[1] 曲丽暖 孙海燕[1] 王红娟[1] 马韦韦[1] 徐延波[1] 

机构地区：[1]中国人民解放军第107医院胃肠外科

出　　处：《中国生化药物杂志》2017年第7期199-201,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的分析胃乃安胶囊联合心理干预对晚期胃癌化疗患者免疫功能及生活质量的影响。方法纳入2014年7月2016年8月中国人民解放军第107医院诊治的130例晚期胃癌患者为研究对象,随机分为2组,2组均行化疗治疗,其中观察组化疗期间服用胃乃安胶囊。对化疗前后2组免疫指标和生活质量以及不良反应进行对比分析。结果化疗后,观察组CD4＋、CD8＋、CD4＋/CD8＋、CD3＋和NK水平均优于对照组（P〈0.05）。化疗后,观察组SF-36评分中身体功能、健康状况、活力、情绪和精神健康得分均优于对照组（均P〈0.05）。观察组胃肠道反应和肝肾功能损伤发生比例为35.38%和21.54%,均低于对照组63.08%和40.00%（均P〈0.05）。结论胃乃安胶囊可提高晚期胃癌化疗患者免疫功能,减小不良反应,从而改善患者生活质量。Objective To investigate the effect of gastric capsule combined with psychological intervention on immune function and quality of life in patients with advanced gastric cancer. Methods A total of 130 patients with advanced gastric cancer were enrolled in this studyfrom July 2014 to August 2016 in our hospital,andrandomly divided into two groups. Twogroups were treated with chemotherapy,andobservation group was treated anotherwith Weinaian capsule. The immune indexes,quality of life and side effects of the 2 groups before and after chemotherapy were compared and analyzed. Results After chemotherapy,CD4＋、CD8＋、CD4＋/CD8＋、CD3＋and NKlevel of observation group were better than that of control group（ all P 〈0. 05）. After chemotherapy,SF-36 score of physical function,health status,vitality,emotional and mental health scores of observation group werebetter than that of control group（ all P 〈0. 05）. During chemotherapy,proportion of gastrointestinal reaction and liver and kidney injury of observation group were 35. 38% and 21. 54%,lower than that of control group 63. 08% and 40. 00%（ all P 〈0. 05）. Conclusion Weinaian capsule can improve immunologic function of advanced gastric cancer patients undergoing chemotherapy and reduce adverse reactions,so as to improve the quality of life of patients.

关 键 词：胃乃安胶囊 心理干预 胃癌 化疗 生活质量 

分 类 号：R735.2[医药卫生—肿瘤]