替普瑞酮治疗老年慢性浅表性胃炎的疗效探讨  

Study on the effect of treatment of chronic superficial gastritis in elderly patients with chronic obstructive pulmonary disease

作　　者：赖人旭[1] 边壮[1] 任江南[1] 高敏照[1] 麦蕾[1] 郭惠学[1] 

机构地区：[1]中山大学附属第五医院消化内科

出　　处：《中国生化药物杂志》2017年第7期261-263,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨替普瑞酮治疗老年慢性浅表性胃炎的临床效果。方法收集中山大学附属第五医院门诊经胃镜诊断为慢性浅表性胃炎的老年患者80例,随机分为对照组和治疗组,每组40例,对照组采用雷尼替丁治疗,治疗组使用替普瑞酮治疗,评价2组药物对老年慢性浅表性胃炎的治疗效果及安全性。结果治疗组总有效率为92.5%,对照组总有效率为75.0%;比较2组患者的治疗总有效率发现,治疗组患者总有效率显著高于对照组（χ~2=4.50,P〈0.05）;治疗组症状平均改善时间为（8.32±2.06）d,对照组症状平均改善时间为（11.69±2.12）d,2组比较差异有明显统计学意义（t=7.21,P〈0.05）,治疗组不良反应发生率为5.0%,对照组不良反应发生率为10.0%,2组比较差异无统计学意义（χ~2=0.18,P〉0.05）。结论替普瑞酮治疗老年慢性浅表性胃炎安全有效。Objective To investigate the clinical effect of the treatment of senile chronic superficial gastritis with the treatment of the elderly patients. Methods Collected in our hospital diagnosed by endoscopy in 80 elderly patients with chronic superficial gastritis were randomly divided into control group and treatment group,40 cases in each group,the control group using ranitidine therapy,treatment group with teprenone treatment,evaluation of 2 groups of drugs on chronic superficial gastritis and therapeutic effect safety. Results The total effective rate of treatment group was92. 5%,control group total effective rate was 75%; the treatment of two patients with total efficiency,the total effective rate in treatment group was significantly higher than the control group（ χ~2= 4. 50,P 〈0. 05）; the average time for improvement of symptoms in the treatment group was（ 8. 32 ±2. 06） days,the average time to improve the symptoms of the control group（ 11. 69 ± 2. 12） days,there was significant difference between the two groups（ t = 7. 21,P 〈0. 05）,the treatment group the incidence of adverse reaction was 5%,the control group adverse reaction rate was 10%,the difference between the two groups was not statistically significant（ χ~2= 0. 18,P 〉0. 05）. Conclusion It is safe and effective for the treatment of chronic superficial gastritis in elderly patients.

关 键 词：替普瑞酮 慢性浅表性胃炎 老年 治疗 效果 

分 类 号：R573.31[医药卫生—消化系统]