二氮嗪对兔膝关节骨关节炎进展的影响的研究  

Effects of Diazoxide on The Development of Osteoarthritis of The Knee Joint in Rabbits

作　　者：陈康[1] 符红娜 段招财 陈泽俊[1,2] 

机构地区：[1]海南医学院临床学院,海口571199 [2]海南医学院附属医院,海口571101

出　　处：《实验动物科学》2017年第3期6-9,共4页Laboratory Animal Science

基　　金：国家级大学生创新创业项目(No.201311810045);海南医学院大学生创新性实验计划项目(No.HYCX201212)

摘　　要：目的研究二氮嗪对兔膝关节骨关节炎进展的影响,并探索其可能的作用机制。方法成年雄性新西兰大白兔20只,通过切断兔双侧膝关节的前交叉韧带和内外侧半月板建立兔膝关节骨关节炎模型;分为二氮嗪组和对照组各10只,术后每周向二氮嗪组关节腔内注射二氮嗪溶液1 m L,对照组关节腔内注射蒸馏水1 m L。在第4周时解剖兔膝关节,进行对比观察。结果 4周后,从实验动物活动表现和大体标本观察,二氮嗪组较对照组骨关节炎病变较轻(P<0.05)。结论二氮嗪对兔膝关节骨性关节炎的进展有一定的对抗作用。Objective To study the effects of diazoxide on the knee osteoarthritis in rabbits and explore the possible mechanism. Method Select 20 adult male New Zealand white rabbits, cut off the bilateral anterior cruciate ligament of knee joint and the lateral meniscus, establish the model of osteoarthritis;randomly devide the rabbits into diazoxide group and control group,10 rabbits per group,Every week after the surgery, give the former diazoxide 1 mL injection in the intra-articular, give the control group distilled water 1 mL injection in the intra- articular. Anatomize the rabbit knee joint at the fourth week, and compare the cartilage lesion of the two groups. Result Observing the animal＇ s capability of motion and rabbit knee specimen, we found the osteoarthritis pathological changes in Diazoxide group is lighter than in control group （P 〈 0.05 ）. Conclusion Diazoxide has a certain antagonism to the development of osteoarthritis of the knee joint in rabbits.

关 键 词：二氮嗪 骨关节炎 氧化损伤 线粒体ATP敏感钾通道 

分 类 号：R36[医药卫生—病理学]