美沙酮、丁丙诺啡和钠洛酮联合治疗美沙酮依赖综合征的可行性及疗效评价--附21例美沙酮依赖脱毒治疗的临床分析  

The viability and treatment effect estimate of using methadone, buprenorphine and naloxone to treat methadone dependence

作　　者：陈银萍 王文甫 裴渝 QUAN Li-xin CAO Li-hong ZHOU Yan CHEN Min 

机构地区：[1]湖南省康达自愿戒毒中心,长沙410007 [2]Kangda voluntary detoxification center of hunan province,changsha410007

出　　处：《中国药物滥用防治杂志》2017年第4期211-213,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨美沙酮、丁丙诺啡和纳洛酮联合治疗美沙酮依赖的可行性及疗效。方法:分析21例美沙酮依赖患者的脱毒治疗结果。治疗先用美沙酮替代递减治疗约5天,然后使用丁丙诺啡、纳洛酮治疗3-5天;且早期联合抗焦虑药和镇静催眠药等治疗。以纳洛酮催瘾试验、稽延性戒断症状量表和患者对治疗满意度评定以及随访操守情况等评价该方法对美沙酮依赖脱毒治疗的有效性和可行性。结果:脱毒成功率95.23%。出院时稽延性戒断症状评分平均(6.40±1.77)分,病人满意度为非常满意者占80.95%。随访时保持操守者12例(57.14%),操守时间平均(9.69±5.90)月。结论:本方法对美沙酮依赖脱毒成功率高,安全性和可行性较好。Objective： To discuss the viability and treatment effect estimate of using methadone, buprenorphine and naloxone to treat methadone dependence. Methods： Explain the result of detoxification treatment of 21 methadone dependent patients. First, using the decreasing treatment of the substitution of methadone for about five days. Then, using buprenorphine and naloxone to cure for the next three to five days. And antianxiety drugs and sedative hypnotic drugs are also used in the early period. Assess the viability and treatment effect of detoxification treatment of methadone dependence by comparing the scale assessment of protracted abstinence, the satisfaction degree assessment of the treatment of the patients and following-up visit and so on. Results： The rate of detoxification is 95.23%. The average score is under ten when doing the scale assessment of protracted abstinence at the time of discharge（6.40±1.77）. When they discharge from hospital, the rate of patients who are very satisfying is 80.95% according to the satisfaction degree assessment of the treatment of the patients. The rate of keeping their personal integrity is 57.14%（9.69±5.90）. conclusion： This way can be used for treating methadone dependence. The rate of successful detoxification is high. It is also safety and feasibility.

关 键 词：美沙酮依赖综合征 丁丙诺啡 纳洛酮 脱毒治疗 

分 类 号：R749.64[医药卫生—神经病学与精神病学]