重复经颅磁刺激对双相情感障碍稳定期患者认知功能的影响  

Effects of repetitive transcranial magnetic stimulation on cognitive function of patients with bipolar affective disorders in stable stage

作　　者：刘宝贵[1] 王龙[1] 杜远[1] 

机构地区：[1]安徽省精神卫生中心,安徽合肥230022

出　　处：《中国民康医学》2017年第10期4-6,22,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨重复经颅磁刺激(r TMS)对双相情感障碍稳定期患者认知功能的影响。方法:纳入双相情感障碍稳定期患者64名,其中女性28名,男性36名。采用θ短阵快速脉冲刺激(TBS)模式刺激左侧前额叶背外侧皮质(DLPFC),每周5次,共干预10次,两周时间完成。于治疗前及2周后应用连线测验(TMTA),符号编码,词语学习(HVLT-R),视觉记忆(BVMT-R),Stroop-单词、颜色及色词,持续操作测验2D、3D及4D进行疗效评定。结果:64例双相情感障碍患者经重复经颅磁刺激(r TMS)治疗前后比较,以及双相情感障碍男女组治疗前后自身比较显示所有测验指标,即连线测验词,持续操作测验2D、3D及4D成绩,均明显优于治疗前(P<0.05);双相情感障碍男女组的组间比较显示,双相情感障碍的男性患者的视觉记忆(BVMT-R)及持续操作测验2D、3D及4D成绩均明显优于女性患者(P<0.05),而连线测验(TMTA),符号编码,词语学习(HVLT-R),Stroop-单词、颜色及色词成绩比较男女组间差异无统计学意义(均P>0.05)。结论:重复经颅磁刺激对双相情感障碍稳定期患者认知功能有改善作用。Objective： To explore effects of repetitive transcranial magnetic stimulation（ r TMS） on cognitive function of patients with bipolar affective disorders in stable stage. Methods： 64 patients with bipolar disorders,including 28 women and 36 men,were included.The theta burst stimulation（ TBS） was used to stimulate the left dorsolateral prefrontal cortex（ DLPFC） for 2 weeks,5 times a week,a total of 10 times. The effects were assessed by using trail marking test A（ TMTA）,symbolic encoding,Hopkins verbal learning revision test-revised（ HVLT-R）,brief visuospatial memory test-revised（ BVMT-R）,Stroop-word,color and color word,and continuous operation test 2D,3D and 4D before and 2 weeks after the treatment. Results： A total of 64 patients completed the study. The scores of TMTA and continuous operation test 2D,3D and 4D of all the patients after the treatment were higher than those before the treatment（ P〈0.05）. The comparisons of the male group and the female group showed that： the scores of BVMT-R and continuous operation test 2D,3D and 4D of the male group were better than those of the female group（ P〈0.05）,while the differences of TMTA,symbolic encoding,HVLT-R and Stroop-word,color and color word were not statistically significant（ all P〉0.05）. Conclusions： Repetitive transcranial magnetic stimulation can improve the cognitive function of the patients with bipolar disorders in the stable stage.

关 键 词：重复经颅磁刺激 双相情感障碍 认知功能 

分 类 号：R742.5[医药卫生—神经病学与精神病学]