心理社会干预联合帕利哌酮对首发精神分裂症患者一年结局的影响  

Effects of psychosocial interventions combined with Paliperidone on one-year outcomes of first-episode schizophrenia patients

作　　者：张延赤 尹洪影 田润辉[2] 王丽华 赵富帅 

机构地区：[1]长春市第六医院,吉林长春130052 [2]吉林大学第一临床医院

出　　处：《中国民康医学》2017年第10期17-19,50,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较单用帕利哌酮与结合心理社会干预对首发精神分裂症患者1年结局的影响。方法:选取符合DSM-IV诊断标准的80例首发精神分裂症患者采用完全随机分组分为单用帕利哌酮组(对照组)和帕利哌酮结合心理社会干预组(研究组),每组各40例,治疗1年,评测其疗效。结局主要指标:社会功能缺陷量表(SDSS)评分和世界卫生组织生活质量测定简表(WHOQOL-BRIEF)评分,次要指标:威斯康辛卡片分类测验(WCST)结果、家庭亲密度与适应性量表(FACESⅡ-CV)评分及临床治愈率(定义为PANSS各项目均≤3分且持续6个月)。结果:研究组在SDSS量表中"职业和工作"、"社会性退缩"、"对外界的兴趣和关心"及"责任心和计划性"4个项目评分均明显低于对照组,差异有统计学意义(P<0.05);在WHOQOL-BRIEF评分中,研究组在心理领域和社会关系的评分显著高于对照组,差异有显著统计学意义(P<0.01);研究组的FACESⅡ-CV总分明显优于对照组(P<0.05);研究组临床治愈率高于对照组,但差异无统计学意义。结论:心理社会干预治疗联合帕利哌酮有助于首发精神分裂症患者的症状改善和功能恢复。Objective： To compare effects of single Paliperidone and Paliperidone combined with psychosocial interventions on one-year outcomes of first-episode schizophrenia patients. Methods： 80 first-episode schizophrenia patients diagnosed by DSM-IV were randomly assigned to single Paliperidone group（ control group,40 cases） and Paliperidone combined with psychosocial interventions group（ study group,40 cases）. The treatment lasted for 12 months. The main outcomes were the scores of social disability screening schedule（ SDSS） and WHO quality of Life-Brief（ WHOQOL-BRIEF）. The second outcomes were Wisconsin card sorting test（ WCST） results,family adaptability and cohesion scale,second edition-Chinese version（ FACESⅡ-CV） score and clinical recovery rate（ defined as all subscales of PANSS less than 3 for at least 6 months）. Results： The scores of carrier and work,social withdraw,interests and care for outside and responsibility and planning of SDSS of study group were significantly lower than those of control group,and the differences were statistically significant（ P〈0.05）. The psychology and social relationship scores of WHOQOL-BRIEF of study group were significantly higher than those of control group,and the differences were statistically significant（ P 〈 0. 05）. The clinical recovery rate was higher in study group than control without a significant difference. Conclusions： The combination of psychosocial interventions and Paliperidone is useful to improve the symptoms and functionrecovery of the first-episode schizophrenia patients.

关 键 词：心理社会干预 帕利哌酮 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]