盐酸伊托必利对功能性消化不良患者胃容受性的影响  

Effect of Itopride Hydrochloride on the Gastric Accommodation on Patients with Functional Dyspepsia

作　　者：杨云 

机构地区：[1]江苏省常州市金坛区中医医院消化内科,江苏常州213200

出　　处：《中外医疗》2017年第16期140-142,共3页China & Foreign Medical Treatment

摘　　要：目的探讨盐酸伊托必利对功能性消化不良(Functional dyspepsia,FD)患者的临床疗效及胃容受性功能的影响。方法方便选取该院2013年6月—2016年9月消化科治疗的FD门诊患者120例为研究对象,随机分为治疗组(给予盐酸伊托必利)和对照组(给予曲美布汀)各60例,2组疗程均为4周,观察两组患者治疗前后胃容受性变化、比较两组临床疗效。结果治疗4周后两组饮水负荷量均较治疗前升高,治疗组升高更明显[治疗组升高(67.6±25.8)m L,对照组升高(31.5±24.9)m L,(P<0.05)];治疗组总有效率为86.7%,其中显效18例(30.0%)、有效34例(56.7%);对照组总有效率为56.7%,其中显效16例(26.7%),有效18例(30.0%),治疗组与对照组临床疗效比较差异有统计学意义(P<0.05)。结论患者使用盐酸伊托必利能有效的改善患者胃容受性障碍,缓解患者上腹胀痛、早饱等症状;盐酸伊托必利治疗FD有良好的的疗效。Objective To observe the clinical curative effect of itopride hydrochloride on the gastric accommodation on patients with functional dyspepsia and effect on the gastric accommodation. Methods 120 cases of FD outpatients treated in the hospital from June 2013 to September 2016 were convenient selected and randomly divided into two groups with 60 cases in each, the treatment group and the control group were respectively treated with itopride hydrochloride and trimebutine,and the treatment course of both groups was four weeks, and the changes of gastric accommodation before and after treatment were observed and the clinical curative effect was compared between the two groups. Results After four-week treatment, the drinking load capacity of the two groups after four-week treatment increased compared with that before treatment,and the increase in the treatment group was more obvious [increase in the treatment group（67.6±25.8）mL, increase in the control group（31.5±24.9）mL,（P〈0.05）, the total effective rate in the treatment group was 86.7%, 18 cases were markedly effective（30.0%）, 34 cases were effective（56.7%）, and in the control group, the total effective rate was 56.7%, 16 cases were markedly effective（26.7%） and 18 cases were effective（30.0%）, and the difference in the clinical curative effect between the treatment group and the control group was statistically significant（P〈0.05）. Conclusion The itopride hydrochloride can effectively improve the gastric accommodation disorders of patients and relieve the symptoms of epigastric distention and satiety, and the curative effect of itopride hydrochloride in treatment of FD is good.

关 键 词：盐酸伊托必利 功能性消化不良 胃容受性 

分 类 号：R57[医药卫生—消化系统]