复方樟柳碱联合腺苷钴胺治疗缺血性视神经病变  

Compound anisodine combined with adenosine in the treatment of ischemic optic neuropathy

作　　者：夏蓉[1] 卜艳丽[1] 冯春阳[1] 周莅斌[1] 

机构地区：[1]攀枝花学院附属医院眼科,四川攀枝花617000

出　　处：《西部医学》2017年第8期1133-1136,共4页Medical Journal of West China

基　　金：四川省科技支撑计划项目(2012SZ01048)

摘　　要：目的探讨复方樟柳碱联合腺苷钴胺治疗缺血性视神经病变的临床效果。方法将2015年5月~2016年5月入院的52例缺血性视神经病变患者共76只患眼随机分为对照组和实验组,每组各38只眼,对照组患眼给予复方樟柳碱治疗,实验组患眼再加用腺苷钴胺,比较两组患眼治疗有效率,治疗前后视力分布情况,视力、视野缺损、相应血管血流参数与彩色动脉血流图。结果实验组患眼治疗总有效率明显高于对照组,治疗后视力分布情况明显优于对照组,差异均具有统计学意义(P<0.05);治疗后实验组视力水平显著高于对照组,视野缺损水平显著低于对照组(P<0.05);治疗后实验组CRA、OA与SPCA的PSV、EDV与TAMX水平均高于对照组(P<0.01);两组患眼治疗后CRA、OA与SPCA动脉血流速度均有所提高,而实验组改善效果更为显著。结论复方樟柳碱联合腺苷钴胺治疗缺血性视神经病变效果明显,可在临床推广应用。Objective To investigate the clinical effect of compound anisodine combined with adenosine Cobalt on the treatment of patients with ischemic optic neuropathy. Methods 76 eyes of 52 patients with ischemic optic neuropathy who accepted therapy in our hospital from May 2015 to May 2016 were randomly divided into control group and experi- mental group. The patients in control group were given compound anisodine to the eyes. The patients in experimental group were given compound anisodine plus adenosin cobalt amine to the eyes. The total effective rate, visual acuity distri- bution, visual acuity, visual field defect, the corresponding blood vessel parameters and color arterial blood flow were compared between the two groups. Results The total effective rate of the experimental group was significantly higher than that of the control group, and the distribution of visual acuity after treatment was significantly better than that of the control group （P 〈0.05）. The level of visual field defect in the visual acuity group was significantly lower than that in the control group （P〈0.05）. After treatment, the levels of PSV, EDV and TAMX in CRA, OA and SPCA were signif- icantly higher than those in control group （P 〈0.01）. The blood flow velocities of CRA, OA and SPCA were improved in both groups after treatment, and the improvement extent of the experimental group was more significant （P〈0.05）. Conclusion The comprehensive intervention effect of compound anisodine plus adenosine Cobalt amine in the treatment of ischemic optic neuropathy is significant.

关 键 词：复方樟柳碱 腺苷钴胺 缺血性视神经病变 视力 动脉血流 

分 类 号：R774.6[医药卫生—眼科]