2053例星形细胞瘤临床病理观察  

Clinical pathology observation in 2 053 cases of astrocytoma

作　　者：王晓开[1] 刘春英[1] WANG Xiao-kai LIU Chun-ying(Liaoning University of Traditional Chinese Medicine ,Shenyang 110032 ,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110032

出　　处：《临床军医杂志》2017年第7期718-722,共5页Clinical Journal of Medical Officers

摘　　要：目的观察2 053例星形细胞瘤的病理特点并验证神经胶质纤维酸性蛋白(GFAP)、中枢神经特异蛋白(S-100)、波形蛋白(Vim)、增殖指数(ki67)在星形细胞瘤中的表达。方法回顾性分析自1955—2010年沈阳军区总医院收治的2 053例星形细胞瘤患者的临床资料,光镜结合免疫组化染色观察其病理学特征并行GFAP、S-100、Vim、ki67检测。结果 2 053例星形细胞瘤患者男女比为1.35∶1.00;各年龄段均有发生,30~50岁发病概率较大。星形细胞瘤的组织学形态多样化,可分为8类。GFAP、S-100、Vim及ki67的阳性率分别约为95.9%(1 969/2 053)、92.0%(1 889/2 053)、90.7%(1 863/2 053)及100.0%。结论星形细胞瘤为常见的原发性脑肿瘤,好发于男性,局部侵袭性强,易复发,组织形态多样化,免疫表型GFAP、S-100、Vim,GFAP和ki67的阳性指数与其恶性程度有关。Objective To investigate the clinical pathologic features and confirm the immunohistochemical expression of GFAP,S-100,Vim and ki67 in astrocytoma. Methods A retrospective study was performed on 2 053 cases of patients with astrocytoma who were admitted from 1955 to 2010. Light microscope combined with immunohistochemical staining to observe its pathological features and made parallel detection of GFAP,S-100,Vim and ki67. Results The 2 053 cases of patients with astrocytoma male to female ratio of 1. 35： 1. 00; various ages have occurred,the incidence of 30 to 50 year-old was the majority. The astrocytoma histologic diversity,can be divided into 8 categories. The positive rate of GFAP,S-100,Vim and ki67 was 95. 9%（ 1 969/2 053）,92. 0%（ 1 889/2 053）,90. 7%（ 1 863/2 053） and approximately 100. 0%. Conclusion The astrocytoma is a common primary brain tumor,good incidence in male,locally aggressive,easy to relapse,diversification of morphology,immune phenotype GFAP,S-100,Vim,GFAP and ki67 positive index level may be related to the level of malignancy.

关 键 词：星形细胞瘤 原发性脑肿瘤 神经上皮源性肿瘤 病理 

分 类 号：R730.264[医药卫生—肿瘤]