Exploring pre-degenerative alterations in humans using induced pluripotent stem cell-derived dopaminergic neurons  

作　　者：Federica Bono Chiara Fiorentini 

机构地区：[1]Division of Pharmacology, Department of, Molecular andTranslational Medicine, University of Brescia, Brescia, Italy

出　　处：《Neural Regeneration Research》2017年第7期1068-1070,共3页中国神经再生研究（英文版）

基　　金：supported by "C.Golgi" Foundation,Brescia,Italy

摘　　要：Understanding the cellular and molecular mechanisms underlying human neurological disorders is hindered by both the complexity of the disorders and the lack of suitable experimental models recapitulating key pathological features of the disease.This is a crucial issue since a limited understanding of pathogenic mechanisms precludes the development of drugs counteracting the progression of the disease.Among neurological disorders,Understanding the cellular and molecular mechanisms underlying human neurological disorders is hindered by both the complexity of the disorders and the lack of suitable experimental models recapitulating key pathological features of the disease.This is a crucial issue since a limited understanding of pathogenic mechanisms precludes the development of drugs counteracting the progression of the disease.Among neurological disorders,

关 键 词：in Exploring pre-degenerative alterations in humans using induced pluripotent stem cell-derived dopaminergic neurons stem DAT been that of cell PSC 

分 类 号：R741[医药卫生—神经病学与精神病学]