正常体重青少年睡眠状况与糖耐量受损相关性研究  

Study on the association between sleeping status and impaired glucose tolerance among normal weight adolescents

作　　者：李丽雯[1] 赵克娜[1] 赵安达 吕佳骏 张锦文[1] 王晓斌[1] 李生慧[1] 

机构地区：[1]上海交通大学医学院公共卫生学院,上海200127

出　　处：《中国学校卫生》2017年第7期967-971,共5页Chinese Journal of School Health

基　　金：国家自然科学基金面上项目(81673183);上海市公共卫生优秀学科带头人培养计划项目(GWDTR201222)

摘　　要：目的探讨正常体重青少年睡眠状况与身体糖耐量受损的相关性,为及早预防糖代谢异常相关疾病的发生提供参考。方法基于中国安徽代谢综合征研究,选取12.6~18.9岁正常体重青少年男性412名和女性317名,分析睡眠质量、睡眠呼吸障碍、睡眠时间与血糖水平、空腹糖耐量受损和糖耐量受损之间的相关性。结果在正常体重男生中,校正年龄、BMI-Z评分、发育阶段、吸烟、饮酒和学历等因素后,睡眠质量差、睡眠呼吸障碍与糖耐量受损发生率之间呈正相关[OR值(OR值95%CI)PSQI评分为1.449(1.158~1.813),P=0.012;PSQI≥6分为4.643(1.718~12.548),P=0.003;PSQI≥5分为4.737(1.898~11.827),P=0.001;SDB为2.972(1.010~8.746),P=0.048]。睡眠时间长与糖耐量受损的发生率呈负相关[OR值(OR值95%CI)睡眠时间为0.568(0.404~0.797),P=0.001;睡眠时间<8 h为3.528(1.399~8.896),P=0.008]。结论睡眠质量差和睡眠时间不足可能增加正常体重男性青少年糖耐量异常的发生率,而在女生该趋势并不明显。Objective To explore the association between sleeping status and impaired glucose tolerance among normal weight adolescents, and to provide a reference for early prevention of related diseases caused by impaired glucose metabolism.Methods Based on the Chinese Metabolic Syndrome Cohort Study in Anhui province,412 boys and 317 girls of normal weight aged 12. 6 to 18. 9 years were taken as objects. And the related data was collected to analyze the correlation between sleeping characteristics, including sleep duration, sleep quality, and sleep disordered breathing（ SDB） with fasting blood glucose level, impaired fasting glucose（ IFG） and impaired glucose tolerance（ IGT）. Results In the group of male adolescents of normal weight, a significantly positive correlation under fully adjusted model was found among age, BMI-Z, development stage, education on smoking and drinking, and the risk of PSQI, poor sleep quality, SDB with IGT probability [OR（ 95% CI） PSQI： 1. 449（ 1. 158-1. 813）, P =0. 012; PSQI ≥ 6： 4. 643（ 1. 718-12. 548）, P = 0. 003; PSQI ≥ 5： 4. 737（ 1. 898-11. 827）, P = 0. 001 SDB： 2. 972（ 1. 010-8. 746）, P = 0. 048]. In addition, sleep duration was negatively correlated with the probability of IGT[OR（ 95%CI） sleep duration：0. 568（ 0. 404-0. 797）, P = 0. 001; sleep duration8 h： 3. 528（ 1. 399-8. 896）, P = 0. 008]. Conclusion The poor sleep quality and insufficient sleeping time could increase the risk of abnormal glucose tolerance among male adolescents of normal weight, but this trend is not obvious in the female group.

关 键 词：睡眠异常 葡萄糖耐受不良 人体质量指数 回归分析 青少年 

分 类 号：R338.63[医药卫生—人体生理学] R195[医药卫生—基础医学]