Antimicrobial Efficacy of Curcumin Formulations byPhotodynamic Therapy  

作　　者：Kate C. Blanco Natalia M. Inada Fernanda M. Carbinatto Vanderlei S. Bagnato 

机构地区：[1]University of S6o Paulo, Sao Carlos Institute of Physics, Sao Paulo 13566-590, Brazil

出　　处：《Journal of Pharmacy and Pharmacology》2017年第8期506-511,共6页药剂与药理学（英文版）

摘　　要：URTI （upper respiratory tract infections） are caused by acute, chronic or recurrent infections including pharyngitis andtonsillitis. The etiologic agents involved are bacteria, virus, and fungi. The standard treatment for bacterial infections is the use ofantibiotics. The antibiotic resistance, side effects of drugs and URTI complications indicate the importance of new therapies. PDT（photodynamic therapy） is a treatment option with a fast onset of action, low side effects, and easy administration of PS（photosensitizer） based on this study. The main aim of this study was to develop a new modality for the treatment of infectiouspharyngotonsillitis by photodynamic therapy. In addition, this study aims to evaluate components of the therapy as the PS, curcumin,in two formulations and irradiation conditions in the effectiveness of treatment. The procedure consists of two steps： oraladministration of CFs （curcumin formulations） containing a PS and illumination （450 nm and 0-60 J/cm2）. Bacterial isolates wereobtained from patients in a routine clinical pratice. The new methodology has been developed from the principle ofPI （photodynamicinactivation）. The strain identification number of colony forming units determined the efficacy of PI using each component, lightingand PS. The use of curcumin formulations in PI presented microbial reduction of 5 log.

关 键 词：Upper respiratory TRACT infections  pharyngitis  tonsillitis  curcumin  photodynamic therapy  clinical isolates  syrup  gum. 

分 类 号：R[医药卫生]