调强放疗联合不同化疗方案治疗局部晚期鼻咽癌的近期疗效观察  

Short-term outcomes of intensity-modulated radiation therapy combined with different concurrent chemotherapy regimens in patients with local advanced nasopharyngeal carcinoma

作　　者：庞强[1] 陆合明[1] 陈甲信[1] 刘绪[1] 殷立亮[1] 翁敬锦[2] 邓珊[1] 

机构地区：[1]广西壮族自治区人民医院肿瘤中心放疗科,南宁530021 [2]广西壮族自治区人民医院耳鼻咽喉头颈肿瘤科,南宁530021

出　　处：《中国临床新医学》2017年第7期611-614,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西卫计委科研课题(编号:Z2014201)

摘　　要：目的对比局部晚期鼻咽癌患者调强放疗时分别联合奈达铂+5-Fu(NF)或奥沙利铂+5-Fu(OF)化疗的临床疗效。方法回顾性分析2016-02~2016-05在广西壮族自治区人民医院肿瘤中心收治的40例局部晚期鼻咽癌患者,其中一组采用调强放疗联合NF方案同步化疗(NF组),另一组则采用调强放疗联合OF方案同步化疗(OF组),每组20例,比较两组患者的近期临床治疗效果及不良反应发生情况。结果治疗1个月后,两组疗效差异无统计学意义(P>0.05);NF组3级以上严重不良反应中,除口腔黏膜反应高于OF组(P<0.05)外,其他不良反应两组的发生率均低于10%,差异无统计学意义(P>0.05)。结论调强放疗联合NF方案与OF方案同步化疗治疗局部晚期鼻咽癌的近期疗效相当,OF组的重度口腔黏膜反应相对较低。Objective To assess the short-term outcomes of intensity-modulated radiation therapy（ IMRT）combined with concurrent nedaplatin plus 5-flurouracil（ NF regimen） or oxaliplatin plus 5-fluorouracil（ OF regimen）in patients with local advanced nasopharyngeal carcinoma（ NPC）. Methods 40 patients with local advanced NPC were treated at the clinical cancer center of the People＇s Hospital of Guangxi Zhuang Autonomous Region during February 2016 and May 2016,and their clinical data were retrospectively analyzed. Of the 40 patients,20 cases（ NF group） were treated with IMRT and concurrent NF chemotherapy,and the other 20 cases（ OF group） were treated with IMRT and concurrent OF chemotherapy. The short-term outcomes and toxicities were compared between the two groups. Results There was no significant difference in the clinical effect between the two groups 1 month after treatmeant（ P〉0. 05）. In the severe adverse reactions of grade 3,the NF group had a significantly higher rate of oral mucositis than the OF group（ P〈0. 05）,except for this,there were no significant differences in the incidences of other severe adverse reactions between the two groups,with all of the incidences being ≤10%. Conclusion The shortterm clinical effect of IMRT plus concurrent NF regimen is equivalent to that of IMRT plus concurrent OF regimen.However,the latter regimen has less severe oral mucositis.

关 键 词：局部晚期鼻咽癌 奈达铂 奥沙利铂 近期疗效 毒性反应 

分 类 号：R739.63[医药卫生—肿瘤]