光学相干断层扫描血管造影(OCTA)在角膜厚度测量中的临床研究  

Measurement of corneal thickness by optical coherence tomography angiography

作　　者：朱佩文[1] 邹雪香 刘康成 韩云[3] 林志荣[3] 叶蕾[1] 申眉 康红花 周双双[2] 谭钢[2] 邵毅[1] 

机构地区：[1]南昌大学第一附属医院眼科,江西省南昌市330006 [2]南华大学附属第一医院眼科,湖南省衡阳市421001 [3]厦门大学眼科研究所,福建省厦门市361102

出　　处：《眼科新进展》2017年第8期732-735,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81660158;81160118;81160148;81460092;81400372;81400424);江西省远航工程(编号:2014022);江西省自然科学基金重大项目(编号:20161ACB21017);江西省青年科学基金(编号:20151BAB215016;20161BAB215198);江西省重点研发项目(编号:20151BBG70223);江西省教育厅重点项目(编号:GJJ160020);江西省教育厅科技计划项目(编号:GJJ160122);江西省卫计委科技计划项目(编号:20164017;20175115;20175116);江西省卫计委中医药科技计划项目(编号:20150823)~~

摘　　要：目的利用光学相干断层扫描血管造影(optical coherence tomography angiography,OCTA)技术分析健康受试者角膜及角膜上皮各区域的厚度。方法利用OCTA分析100例(男女各50例)年龄20~30岁的健康受试者,使用Angio Vue OCTA系统的视网膜成像模式,并采用SSADA算法进行成像,测量角膜中央9 mm直径范围各区域角膜及角膜上皮厚度,比较不同性别各区域角膜及角膜上皮厚度的差异性。结果男女两组受检者角膜中央总厚度分别为(559.92±33.26)μm、(540.06±31.63)μm,角膜上皮总厚度分别为(57.78±4.88)μm、(56.88±4.57)μm,男性角膜中央总厚度及角膜上皮厚度均大于女性,差异均有统计学意义(t=3.06、2.10,均为P<0.05)。男性各环角膜总厚度均在S5、S7、SN9处最厚,与女性相比,只有在S5、S7处差异显著(t=2.93、2.83,均为P<0.05),女性各环在S5、SN7、SN9处最厚,与男性相比只在S5处差异显著;男性受检者角膜在IT处最薄,与相同区域的女性受检者相比只有在IT5处差异有统计学意义(t=2.02,P<0.05);女性受检者角膜在T5、IT7、T9处最薄,与同区域的男性受检者相比只在T5、T9处差异均有统计学意义(t=2.63、2.20,均为P<0.05);在ST处男女角膜厚度差异显著(t=3.11、2.79、2.33,均为P<0.05);男性受检者角膜上皮在IT5、I7、I9处最厚,在S5、S7、S9处最薄,与同区域的女性相比差异均无统计学意义(均为P>0.05),女性受检者角膜上皮在IT5、T7、N9处最厚,在SN5、S7、S9处最薄;除M2、SN5外,角膜上皮在男女组间差异均无统计学意义(均为P>0.05)。角膜中央上皮占角膜总厚度的百分率最大,并且由内向外逐渐减小。结论 OCTA能够用于测量角膜及角膜上皮各区域的厚度。Objective To analyze the thickness of cornea and corneal epithelium in healthy subjects by optical coherence tomography angiography （OCTA）.Methods Totally 100 healthy subjects aged between 20 and 30 years were analyzed by OCTA technique.Using AngioVue OCTA system of retinal imaging mode,and using SSADA algorithm for imaging,the cornea and the corneal epithelium in the central corneal diameter range of 9 mm were measured.The differences of corneal and corneal epithelial thickness in different gender regions were compared.Results In the male and female group,the corneal central total thickness were（559.92±33.26）μm and（540.06±31.63）μm,and the corneal epithelial thickness were（57.78±4.88）μm and（56.88±4.57）μm,The total central corneal thickness and central corneal epithelial thickness of the male were greater than those of the female,the difference was statistically significant （t=3.06,2.10;all P〈0.05）.The cornea of male was the thickest at S5,S7 and SN9,there were significant differences at S5 and S7 compared with female （t=2.93,2.83;all P〈0.05）;The female cornea was the thickest at S5,SN7 and SN9,and the difference was significant at S5 compared with male.The cornea of male subjects was the thinnest at IT,which was statistically significant only at IT5 compared with female subjects in the same area（t=2.02,P〈0.05）;The cornea of female subjects was the thinnest at T5,IT7 and T9,which was statistically significant only at T5 and T9 compared with male subjects in the same region （t=2.63,2.20;all P〈0.05）;There was significant difference in corneal thickness between male and female at ST （t=3.11,2.79,2.33;all P〈0.05）.The corneal epithelium was the thickest at IT5,I7,and I9,and the lowest at S5,S7 and S9,and there was no significant difference compared with female in the same region （all P〉0.05）.The corneal epithelium of female at the IT5,T7,N9 were the thickest,SN5,S7,S9 were the thinnest;Except for M2 and SN5,there was no significant differences in corneal e

关 键 词：光学相干断层扫描血管造影 角膜厚度 角膜上皮厚度 

分 类 号：R772.2[医药卫生—眼科]