沙利度胺联合含小剂量地塞米松的改良VAD方案治疗多发性骨髓瘤的临床分析  

Clinical Analysis of Thalidomide Combined With Small Dose Dexamethasone Modified VAD Regimen in the Treatment of Multiple Myeloma

作　　者：胡娜[1] 

机构地区：[1]沭阳县人民医院血液科,江苏宿迁223600

出　　处：《中国继续医学教育》2017年第16期166-168,共3页China Continuing Medical Education

摘　　要：目的分析沙利度胺联合含小剂量地塞米松的改良VAD方案治疗多发性骨髓瘤的临床效果。方法收取我院50例多发性骨髓瘤患者,收取时间在2011年10月—2016年10月,并将多发性骨髓瘤患者分为两组,对照组(25例患者实施沙利度胺联合常规VAD方案治疗),观察组(25例患者实施沙利度胺联合含小剂量地塞米松的改良VAD方案治疗),将两组多发性骨髓瘤患者的治疗效果实施对比。结果观察组多发性骨髓瘤患者治疗后血沉(58.89±12.71)mm/h、血钙(0.66±0.31)mmol/L、M蛋白(29.06±10.10)g/L、血红蛋白(26.51±12.01)g/L优于对照组(P<0.05),观察组多发性骨髓瘤患者中在不良反应方面低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论沙利度胺联合含小剂量地塞米松的VAD方案治疗多发性骨髓瘤与沙利度胺联合常规VAD方案治疗具有相同临床效果,且不良反应较沙利度胺联合常规VAD方案治疗小,有利于治疗,促进患者康复。Objective To analyze the clinical efficacy of thalidomide combined with modified VAD regimen containing small dose of dexamethasone in the treatment of multiple myeloma. Methods To collect 50 patients with multiple myeloma in our hospital, the time between October 2011 to October 2016, and the patients with multiple myeloma were divided into two groups, control group（25 patients received thalidomide combined with conventional VAD treatment）, observation group（25 patients received thalidomide combined with a small dose of dexamethasone modified VAD regimen）, therapeutic effects of the two groups of multiple myeloma patientswere compared. Results The observation group of patients with multiple myeloma treatment after ESR（58.89±12.71） mm/h, Ca（0.66±0.31） mmol/L, M protein（29.06±10.10） g/L, hemoglobin（26.51±12.01） g/L was better than that of control group（P〈0.05）, adverse reactions in the observation group and the multiple myeloma group were lower than those in the control group（P〈0.05）. The incidence of adverse reactions in observation group was lower than that in control group（P〈0.05）. Conclusion Thalidomide combined with low-dose dexamethasone for VAD treatment of multiple myeloma and thalidomide combined with conventional VAD regimen has the same clinical effect, Compared with thalidomide and conventional VAD regimen, the adverse reaction is less, which is beneficial to the treatment and promotes the rehabilitation of the patients.

关 键 词：沙利度胺 小剂量地塞米松 VAD方案 多发性骨髓瘤 临床效果 不良反应 

分 类 号：R73[医药卫生—肿瘤]