五羟色胺信号系统与胃肠道疾病的研究进展  

Serotonin signaling system and gastrointestinal diseases

作　　者：郝晓冬[1] 段志军[1] Xiao-Dong Hao Zhi-lun(Duan, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China)

机构地区：[1]大连医科大学附属第一医院,辽宁省大连市116011

出　　处：《世界华人消化杂志》2017年第19期1697-1704,共8页World Chinese Journal of Digestology

摘　　要：五羟色胺(5-hydroxytryptamine,5-HT)是脑肠轴调控路径中的一个重要组成部分.5-HT信号系统在多种胃肠道疾病的发病机制中扮演重要的角色,参与调节胃肠运动、感觉及分泌等功能.5-HT的合成、释放、与特异性受体结合及再摄取过程中任意一个环节发生异常,均与胃肠道功能紊乱的发生密切相关,其不仅在功能性疾病中存在作用,与器质性疾病也有很大的关系.临床上5-HT受体激动剂、拮抗剂及选择性再摄取抑制剂已被广泛运用到多种胃肠道疾病的治疗中.本文阐述了5-HT信号系统与胃肠道疾病病理生理的关系,从而研究5-HT受体在胃肠道中的作用及其相关药物的临床效用,为胃肠道疾病的防治提供理论依据.Serotonin 5-hydroxytryptamine （5-HT） is an important component of the signaling pathways of the brain-gut axis. 5-HT signaling system can regulate gastrointestinal motility,sensoryand secretory an important role in functions, and plays the pathogenesis of gastrointestinal diseases. When the dysfunction of the synthesis, release, specific receptor binding or re-uptake process of 5-HT occurs, gastrointestinal disorders, including both functional diseases and organic diseases, may develop. Clinically, 5-HT receptor agonists, antagonists and selective reuptake inhibitors have been widely used in the treatment of multiple gastrointestinal disorders. This paper summarizes the relationship of the 5-HT signaling system with the pathophysiology of gastrointestinal diseases and discusses the role of 5-HT receptor in the gastrointestinal tract and the clinical utility of related drugs, with an aim to provide a theoretical basis for the prevention and treatment of gastrointestinal diseases.

关 键 词：五羟色胺 五羟色胺受体 五羟色胺转运体 胃肠道疾病 

分 类 号：R57[医药卫生—消化系统]