MMP-9和EGFR在上皮型恶性腹膜间皮瘤的表达及意义  

Expression and significance of MMP-9 and EGFR in epithelial malignant peritoneal mesothelioma

作　　者：杨雨鑫[1] 梁育飞[1] 史永红[2] 郑国启[1] Yuxin Liang YufeiI Shi Yonghong Zheng Guoqi(Department of Gastroenterology,Cangzhou Central Hospital of Hebei Province, Cangzhou 061001, China Department of Pathology, Hebei Medical University, Shijiazhuang 050017, China)

机构地区：[1]沧州市中心医院消化内科,河北省061001 [2]河北医科大学病理学教研室,石家庄050017

出　　处：《中华消化病与影像杂志（电子版）》2017年第3期108-113,共6页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的检测上皮型恶性腹膜间皮瘤组织中基质金属蛋白酶-9(matrix metalloproteinase,MMP-9)和表皮生长因子受体(epidermal growth factor receptor,EGFR)的表达及与预后的关系。方法选取2011年1月至2012年12月沧州市中心医院收治的上皮型恶性腹膜间皮瘤20例,超声引导下穿刺或手术获取腹膜组织,病理及免疫组织化学确诊为上皮型腹膜间皮瘤。应用免疫组织化学S-P法检测腹膜组织中MMP-9和EGFR的表达,并分析与年龄、性别、石棉接触等指标的关系,对所有患者进行随访,了解与患者预后的关系。结果 20例上皮型恶性腹膜间皮瘤中:MMP-9及EGFR的阳性表达率分别为75%和85%;多因素分析显示,年龄和EGFR的回归系数分别为0.1260和0.7742,P值分别为0.0074和0.046。MMP-9与患者的生存时间无明显关系(r=-0.3961,P=0.114)。结论在本组上皮型恶性腹膜间皮瘤中,年龄和EGFR是影响恶性腹膜间皮瘤患者生存期的重要因素,而石棉接触、性别及MMP-9与生存期无关。Objective To detect the expressions of matrix metalloproteinase（MMP-9） and epidermal growth factor receptor （EGFR）and their relationships with the prognosis in epithelial malignant peritoneal mesothelioma. Methods Twenty patients with epithelial malignant peritoneal mesothelioma were selected in Cangzhou Central Hospital from January 2011 to December 2012. The peritoneal tissues were obtained by ultrasound guided puncturing and operation, and were diagnosed by pathology and immunohistochemistry. The expressions of MMP-9 and EGFR in peritoneal tissues were detected by immunohistochemistry（ S-P method）. The relationships of the expressions of the two markers and age, gender, asbestos exposure were analyzed. All patients were followed up to understand the relationship between markers and prognosis. Results In 20 patients with epithelial malignant peritoneal mesothelioma,the positive rates of MMP-9 and EGFR were 75% and 85% ,respectively. Multivariate analysis showed that the regression coefficients of age and EGFR were 0. 126 0 and 0. 774 2, and the P values were 0. 007 4 and 0. 046, respectively. There was no significant relationship between MMP-9 and patients＇ survival time （ r = -0. 396 1, P = 0. 114 ）. Conclusion In this group of patients, age and EGFR are important factors influencing the survival, but the influences of asbestos exposure, sex and MMP-9 are not related to the survival of patients with epithelial malignant peritoneal mesothelioma.

关 键 词：腹膜肿瘤 间皮瘤 基质金属蛋白酶9 受体 表皮生长因子 免疫组织化学 预后 

分 类 号：R735.5[医药卫生—肿瘤]