闭合蛋白在脑缺血中的作用  

Roles of occludin in cerebral ischemia

作　　者：杨可[1,2] 王婷[1,2] 张圆[2,3] Yang Ke Wang Thag Zhang Yuan(Graduate School, Guangzhou Medical University, Guangzhou 511436, China Central Laboratory, Shenzhen Second People＇s Hospital, Shenzhen 518035, Chin Department of Pathophysiology, Baotou Medical College, Baotou 014060, Chin)

机构地区：[1]广州医科大学研究生院,510182 [2]深圳市第二人民医院中心实验室,518035 [3]包头医学院病理生理学教研室,014060

出　　处：《国际脑血管病杂志》2017年第6期541-545,共5页International Journal of Cerebrovascular Diseases

基　　金：广东省自然科学基金（2016A030313027）;深圳市科技计划基础研究项目（JCYJ20150330102401097）;内蒙古自然科学基金（2016MS0802）;包头医学院科学研究基金（BYJJ-DF201601）

摘　　要：血脑屏障（blood-brain barrier, BBB）损伤是缺血性卒中的重要病理学改变。闭合蛋白是构成BBB紧密连接的主要组成部分，在维持BBB完整性中发挥着重要作用。脑缺血通过诱导炎性介质、活性氧和基质金属蛋白酶的激活，启动闭合蛋白降解，并使紧密连接－细胞骨架蛋白相互作用发生改变，导致BBB完整性破坏，通透性增高。文章主要阐述了闭合蛋白与BBB、脑水肿和出血性转化之间的关系以及闭合蛋白作为缺血性卒中干预靶点的可能性。Blood-brain barrier （BBB） injury is an important pathological change of ischemic stroke. Occludin constitutes the major component of the tight junction of BBB, which plays a significant role in maintaining the BBB integrity. Cerebral ischemia initiates occludin degradation through the induction of the activation of inflammatory mediators, reactive oxygen, and matrix metalloproteinases, and causes the changes of tight junction cytoskeletal protein interaction, resulting in BBB integrity destruction and increased permeability. This article mainly elaborates the relationships of occludin with BBB, brain edema and hemorrhagic transformation, as well as the possibility of occludin as an intervention target for ischemic stroke.

关 键 词：卒中 脑缺血 闭合蛋白 血脑屏障 脑水肿 脑出血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]