乳腺浸润性筛状癌与筛状结构导管原位癌的临床病理及免疫组化对比分析  

Comparative analysis based on clinicopathology and mmunohistochemistry of invasive cribriform carcinoma of the breast and cribriform structuer of ductal carcinoma in situ

作　　者：曾玉梅[1] 曹晓珊[1] 杜娟[1] 陈应智[1] 储兵[1] ZENG Yumei CAO Xiaoshan DU Juan CHEN Yingzhi CHU Bin(Department Pathology of Zhongshan City People＇s Hospital, Zhongshan, Guangdong, China, 52840)

机构地区：[1]广东省中山市人民医院病理科,广东中山528400

出　　处：《分子诊断与治疗杂志》2017年第4期261-266,共6页Journal of Molecular Diagnostics and Therapy

摘　　要：目的探讨乳腺浸润性筛状癌(invasive cribriform carcinoma,ICC)与筛状结构导管原位癌(ductal carcinoma in situ,DCIS)的临床病理及免疫表型特点。方法收集12例浸润性筛状癌及12例筛状结构导管原位癌的临床资料,对它们进行形态学观察,免疫组化检测,并进行比较。选用的抗体包括CK5/6、CK(34βE12)、P63、Calponin、ER、PR、HER2、E-cad、Ki67。结果临床资料显示ICC患者的平均发病年龄较筛状结构DCIS的大,临床可触及肿物,而ICC腋窝淋巴结转移少见,预后均良好。镜下两者具有极相似的筛状结构,免疫组化结果显示,ICC导管周围肌上皮标记均为阴性,而筛状结构DCIS周围肌上皮标记阳性。结论 ICC与筛状结构DCIS有相似的组织学特征,免疫组化对鉴别诊断有重要意义。Objective To investigate the clinicopathologic characteristics and the immunophenotypic markers of invasive cribriform carcinoma（ICC） in comparison to cribriform structuer of ductal carcinoma in situ（DCIS）.Methods 12 cases of ICC and 12 cases of cribriform structure of ductal carcinoma in situ were collected for this analysis,in which the morphologic features and immunohistochemical expressions were measured and compared.The antibody CK5/6,CK（34βE12）,P63,Calponin,ER,PR,HER2,E-cad,and Ki67 were included in this analysis.Results The median age of onset of ICC was much older referring to the data of the involved cases.The ICC patients were found with palpable tumors,whereas axillary lymph node metastases were rare and the prognoses were satisfied.All cases showed similar cribriform structure in microscopic examinations,the immunostaining for myoepithelial cells clear expressed negative to 12 ICC patients,but showed positive in 12 cases of cribriform structure of ductal carcinoma in situ.Conclusions The histological features of ICC were similar to those found in cribriform structure of ductal carcinoma in situ,the immunohistochemistry was of great significance in diagnosing ICC from the other.

关 键 词：乳腺 病理 浸润性筛状癌 筛状结构 导管原位癌 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]