海南省低收入女性人乳头瘤病毒感染状况及亚型研究  

Study on the prevalence and subtype distributions of human papillomavirus in low-income women in Hainan

作　　者：钟威达 欧武英[2] 陈元花 郭红[1] ZHONG Weida OU Wuying CHEN Yuanhua GUO Hong(Department of Clinical Laboratory, Hainan Maternity Hospital, Haikou, Hainan, China, 570105 Department of Clinical Laboratory, Haikou People＇ s Hospital, Haikou, Hainan, China, 570208)

机构地区：[1]海南妇产科医院检验科,海南海口570105 [2]海口市人民医院检验科,海南海口570208

出　　处：《分子诊断与治疗杂志》2017年第4期267-271,共5页Journal of Molecular Diagnostics and Therapy

基　　金：海南省总工会医疗救助女职工关爱行动帮扶项目资助(201505)

摘　　要：目的了解海南低收入女性宫颈人乳头瘤病毒(human papillomavirus,HPV)感染的现状及亚型分布情况。方法于2016年1月至2016年12月,由海南省总工会及各市县工会组织本省15个市县的1 373名低收入困难女职工进行健康体检,其中汉族935人、非汉族438人。采用基因芯片导流杂交技术对妇女宫颈脱落细胞进行21种HPV基因分型检测。结果在所研究的1 373例妇女中,HPV感染者为192例,总感染率为13.98%(192/1 373)。共检测出19种HPV亚型,HPV感染率排在前5位的亚型从高到低依次为HPV52(3.35%,46/1 373)、HPV51(1.97%,27/1 373)、HPV58(1.97%,27/1 373)、HPVcp8304(1.75%,24/1 373)、和HPV53(1.60%,22/1 373)。不同市县人群的HPV感染率有所不同,差异有统计学意义(P<0.05),HPV感染率最高的市县为海口市(32.35%,11/34),其次是昌江县(24.63%,33/134),不同市县人群HPV感染的优势型别也有所不同。汉族和非汉族人群的HPV感染率分别为14.12%(132/803)和13.70%(60/378),二组相比,差异无统计学意义(P>0.05)。结论海南省低收入女性宫颈HPV感染率相对国内普通人群较低,不同市县人群的HPV感染率及感染型别有所不同,应加强在HPV高感染率地区进行宫颈癌的防控工作。Objective To evaluate the prevalence and subtype distributions of human papillomavirus（HPV） in low-income women in Hainan.Methods 1 373 low-income women from 15 cities of Hainan were organized to conduct a physical examination by the Hainan Provincial Federation of trade unions and the city and county trade unions from January 2016 to December 2016.Among them,935 people were of Han nationality and 438 were of non-Han nationality.The prevalence of 21 subtypes of HPV in the cervical cells of these women was detected using flow-through hybridization and gene chip technology.Results Among the 1 373 women studied,HPV infection was found in 192 cases,with a total infection rate of 13.98%（192/1 373）.19 subtypes of HPV were found in these samples,and the top 5 subtypes of HPV infection from high to low were HPV 52（3.35%,46/1 373）,HPV 51（1.97%,27/1 373）,HPV 58（1.97%,27/1 373）,HPV cp8304（1.75%,24/1 373） and HPV 53（1.60%,22/1 373）.There is a significant difference in the infection rate of HPV in different cities and counties（P0.05）.The highest rate of HPV infection was found in Haikou with an infection rate of 32.35%（11/34）,followed by Changjiang with an infection rate of 24.63%（33/134）.The dominant subtype of HPV infection was also different among different cities and counties.No significant difference was found in the infection rate between women of Han nationality 14.12%（132/803） and non-Han nationality 13.70%（60/378）（P0.05）.Conclusion Compared to the domestic general population,the prevalence of HPV infection in low-income women in Hainan province is relatively low,and the infection rate of HPV and the distribution of infected subtypes vary in different cities and counties.So the goal will be to strengthen the prevention and control of cervical cancer in the area with high HPV prevalence.

关 键 词：低收入人群 基因分型 乳头状瘤病毒 宫颈肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]