MiRNA-3p/5p在肿瘤中的研究进展  

MiRNA-3p/5p in tumor development

作　　者：张凌宇[1] 陈昌杰[2] 杨清玲[2] ZHANG Lingyu CHEN Changjie YANG Qingling(Clinical Testing and Diagnose Experimental Center, Bengbu Medical College, Bengbu, Anhui, China, 233000 Department of Biochemistry ＆ Molecular Biology, Bengbu Medical College, Bengbu, Anhui, China, 233000)

机构地区：[1]蚌埠医学院临床检验与诊断实验中心,安徽蚌埠233000 [2]蚌埠医学院生物化学与分子生物学教研室,安徽蚌埠233000

出　　处：《分子诊断与治疗杂志》2017年第4期284-288,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省教育厅自然科学重大项目(NO:KJ2015ZD29;KJ2016SD37);安徽省自然科学基金(NO:1508085MH159);安徽省高校学科(专业)拔尖人才学术资助重点项目(NO:gxbj ZD2016069);安徽省蚌埠市科技计划项目(NO:20150309);蚌埠医学院研究生创新计划(NO:Byycx1615)

摘　　要：Pre-miRNA经Dicer酶剪切产生2个产物,分别是miRNA-3p和miRNA-5p,以往的研究多数都是以单一的miRNA-3p或者miRNA-5p为主,而miRNA-3p/5p成对调控肿瘤的发生发展却少有报道。本文就近年来miRNA-3p/5p与肿瘤的研究进展做一综述。Pre-miRNA by the Dicer enzyme cuts produced 2 products,miRNA-3p and miRNA-5p,respectively,most of previous studies are dominated by a single miRNA-3p or miRNA-5p,and miRNA-3p/5p into the regulation of tumor development in pairs is rarely reported.In this paper,recent development of miRNA-3p/5p and cancer will be summarized.

关 键 词：miRNA-3p miRNA-5p 肿瘤 作用机制 

分 类 号：R730.2[医药卫生—肿瘤]