多酚类化合物清除内源性甲醛的作用及其机制研究进展  

Research advances in polyphenols scavenging endogenous formaldehyde

作　　者：孙安琪[1,2] 江海鹏[3] 巨修练[1] 

机构地区：[1]武汉工程大学化工与制药学院,湖北武汉430072 [2]武汉工程大学邮电与信息工程学院,湖北武汉430072 [3]武汉工程大学分析测试中心,湖北武汉430072

出　　处：《中国药理学与毒理学杂志》2017年第6期597-606,共10页Chinese Journal of Pharmacology and Toxicology

摘　　要：人体内可产生内源性甲醛,当甲醛生成-清除系统平衡被破坏,将导致内源性甲醛的异常积累,从而引发血管内皮损伤、动脉粥样硬化、心肌损伤和神经退行性疾病等。研究表明,内源性甲醛也是心脑血管疾病致病因子之一,多酚类化合物可作为甲醛的捕获剂通过清除内源性甲醛起到防治心脑血管疾病的作用。Endogenous formaldehyde is generated in the human body. When the system of endogenous formaldehyde generation with scavengation is damaged, excess accumulation of endogenous formaldehyde induces vascular endothelial injury, atherosclerosis, myocardial damage and neurodegenerative diseases. Studies show that endogenous formaldehyde is one of the key factors during the process of cardiovascular and cerebrovascular diseases. Moreover, polyphenols are used as capture agents of endogenous formaldehyde to prevent and treat cardiovascular and cerebrovascular diseases.

关 键 词：甲醛 内源性 多酚 心血管病 脑血管病 代谢 

分 类 号：R99[医药卫生—毒理学]