建立啮齿类酒精饮用动物模型的影响因素及研究进展  

Factors affecting establishment of rodent alcohol drinking models and recent advances

作　　者：刘欣[1,2,3] 张倩倩[1,2] 王圣霞[4] 张旺信[2] 张汉霆[1,5] 

机构地区：[1]泰山医学院药理学研究所,山东泰安271000 [2]泰山医学院基础医学院医学心理学教研室,山东泰安271000 [3]泰山医学院脑科研究所,山东泰安271000 [4]泰安市中心医院眼科,山东泰安271000 [5]Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology,Blanchette Rockefeller Neurosciences Institute,West Virginia University Health Sciences Center

出　　处：《中国药理学与毒理学杂志》2017年第6期607-614,共8页Chinese Journal of Pharmacology and Toxicology

基　　金：山东省政府"泰山学者海外特聘专家"专项基金;山东省自然基金(ZR2014CL011);山东省高等学校科研计划(2016J16LL57);泰山医学院高层次课题孵育计划(2013GCC08);泰山医学院大学生科研基金~~

摘　　要：酒精使用障碍(AUD)是威胁人类健康乃至生命的重要因素之一。世界卫生组织数据显示,全球每年因AUD而死亡的人数约330万。AUD已成为一个全球性公共卫生和社会性问题,但其神经行为学机制并未完全阐明。因此,建立有效和可靠的酒精饮用动物模型对AUD机制的探讨非常重要。本文从动物品系和造模方法等方面进行综述,探讨可能对造模结果造成偏差的相关影响因素,以期对AUD的动物行为学研究有所裨益。Alcohol use disorder（AUD） is one of the main factors that threaten human health and life. WHO data show that about 3.3 million people die each year worldwide due to AUD. AUD has become a global public health concern, but its neurobiological and behavioral mechanisms remain unclear. Therefore, it is particularly urgent to develop valid and reliable animal models to investigate the underlying mechanisms of AUD. This review summarizes the animal species and modeling methods of AUD in order to explore the potential influence on the deviation of modeling in alcohol intake and provide helpful inputs to behavioral research of AUD.

关 键 词：酒精 动物品系 饮酒模型 啮齿类动物 

分 类 号：R-332[医药卫生] R749.62