发酵桦褐孔菌对链脲佐菌素诱导的Ⅱ型糖尿病大鼠降血糖作用的影响  

Hypoglycemic effect of fermented Inonotus obliquus on type II diabetic rats induced by streptozotocin

作　　者：徐正哲[1] 王飞雪[2] 王昊月[2] 马伟平[2] 白金[2] 林墨[3] 李官浩[3] 陈正爱[2] 

机构地区：[1]延边大学附属医院,吉林延吉133000 [2]延边大学医学院,吉林延吉133002 [3]延边大学食品研究中心,吉林延吉133002

出　　处：《食品与机械》2017年第6期176-179,共4页Food and Machinery

基　　金：吉林省科技厅重点项目(编号:20140307011YY);吉林省教育厅重点项目(编号:吉教科合字[2015]第8号)

摘　　要：通过高脂饮食联合腹腔注射链脲佐菌素(streptozotocin,STZ)的方法建立Ⅱ型糖尿病(type 2diabetes mellitus,T2DM)大鼠模型,探讨发酵桦褐孔菌(fermented Inonotus obliquus,FIO)对T2DM大鼠的血糖、血脂及抗氧化作用的影响。结果表明:与模型组相比较,FIO可显著降低T2DM大鼠的空腹血糖(fasting blood glucose,FBG)、促进肝糖原(hepatic glycogen,HGln)合成、改善胰岛素(insulin,INS)抵抗,使总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、游离脂肪酸(free fatty acids,FFA)、低密度脂蛋白(low density lipoprotein,LDL)及丙二醛(malondialdehyde,MDA)含量显著下降,高密度脂蛋白(high density lipoprotein,HDL)含量和超氧化物歧化酶(superoxide dismutase,SOD)的活性显著上升。说明FIO能够降低Ⅱ型糖尿病大鼠血糖,改善脂质代谢及氧化应激水平。To test effects of FIO on blood glucose,blood lipid,and antioxidation in typeⅡ diabetes,the typeⅡ diabetic rat model was established by high fat diet-feeding combined with intraperitoneal injection of STZ.The results showed that FIO significantly lowered FBG levels,promoted synthesis of HGln,and improved insulin resistance in the type Ⅱ diabetic rats,compared to untreated control diabetic animals.In addition,FIO not only significantly decreased TC,TG,FFA,LDL and MDA in serum,but also dramatically increased the HDL in serum and the activities of SOD in type Ⅱ diabetic rats.Our study showed that FIO significantly lowered high blood glucose,improved lipid metabolism and antioxidant ability.

关 键 词：发酵桦褐孔菌 Ⅱ型糖尿病 链脲佐菌素 降血糖作用 

分 类 号：R285.5[医药卫生—中药学]