大剂量甲泼尼龙冲击治疗急性一氧化碳中毒迟发型脑病疗效分析  

Efficacy analysis of high-dose methylprednisolone in the treatment of acute carbon monoxide poisoning with delayed encephalopathy

作　　者：郭文玲[1] 张弘娟[1] Guo Wenling Zhang Hongjuan(Department of Neurology, J iaozuo Coal-mining Groups Central Hospital, J iaozuo 454000, Chin)

机构地区：[1]焦煤(集团)有限责任公司中央医院神经内科,河南焦作454000

出　　处：《中国实用神经疾病杂志》2017年第14期42-43,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析大剂量甲泼尼龙冲击疗法治疗急性一氧化碳中毒迟发型脑病(DEACMP)的临床疗效。方法将46例急性一氧化碳中毒迟发型脑病(DEACMP)患者随机分成观察组23例和对照组23例。对照组采用传统的高压氧疗和药物治疗,观察组在上述疗法的基础上加用大剂量甲泼尼龙冲击治疗。通过对2组治疗前、治疗后2个月的日常生活自理能力(Barthel指数)、简易智力状况检查表(MMSE)的评定,评价临床疗效。结果观察组治疗后Barthel指数和MMSE评分较对照组明显改善,差异有统计学意义(P<0.05)。观察组总有效率91.3%,对照组为60.9%,2组比较差异有统计学意义(P<0.05)。结论大剂量甲泼尼龙冲击治疗DEACMP疗效显著,使患者日常生活自理能力明显提高,认知功能明显改善,减轻痴呆及残疾程度,值得临床推广。Objective To research the efficacy of high-dose methylprednisolone shock therapy in the treatment of acute car- bon monoxide poisoning delayed encephalopathy （DEACMP）, Methods In this study,46 patients with DEACMP treated in our hospital from Nov. 2010 to Mar. 2016 were selected as samples. They were randomly divided into the observation group and control group. The control group was treated hy traditional hyperbaric oxygen therapy and drug treatment. The observation group was treated with high-dose methylprednisolone on the basis of the above-mentioned therapy. The clinical efficacy evaluation of two groups was based on the scores of the self-care ability （Barthel index） and simple intelligence status checklist （MMSE） of patients in the two months before and after the treatment. Results The scores of Barthel and MMSE were significantly improved in the ob- servation group,the difference was statistically significant （P〈0.05）. The total effective rate was 91.3% in the observation group and 60.9% in the ＇control group,the difference was statistically significant （P〈0.05）. Conclusion The results of this study show that the application of high-dose methylprednisolone in clinical treatment could significantly prevent the progress of DEACMP, shorten the course of treatment, and promote patients recovery. Patients＇ self-care ability and quality of life have been significantly improved. It is recommended in clinical Promotion.

关 键 词：大剂量甲泼尼龙冲击疗法 急性一氧化碳中毒迟发型脑病 

分 类 号：R747.9[医药卫生—神经病学与精神病学]