α-硫酸锌联合神经妥乐平对2型糖尿病合并周围神经病变患者血清GGT MDA及GSH-Px水平的影响  

Effect of α-zinc sulfate combined with Neurotropin on serum GGT,MDA and GSH-Px levels in patients with type 2 diabetes mellitus complicated with peripheral neuropathy

作　　者：张秋萍 Zhang Qiuping(Department of Endocrinology, Xinyang Central Hospital, Xinyang 464000,Chin)

机构地区：[1]信阳市中心医院,河南信阳464000

出　　处：《中国实用神经疾病杂志》2017年第14期70-72,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨α-硫酸锌联合神经妥乐平对Ⅱ型糖尿病合并周围神经病变患者血清谷氨酰转肽酶(gamma-glutamyl transferase,GGT)、丙二醛(malondialdehyde,MDA)及谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)水平的影响。方法选取我院收治的100例Ⅱ型糖尿病合并周围神经病变患者,随机分成观察组和对照组各50例,对照组给予神经妥乐平进行治疗,观察组在对照组基础上给予α-硫酸锌治疗,评价2组临床疗效、血清GGT、MDA及GSH-Px水平和安全性。结果观察组临床疗效显著优于对照组,差异有统计学意义(P<0.05);治疗前,2组血清GGT、MDA及GSH-Px水平比较无统计学意义(P>0.05),治疗后2组GGT、MDA水平均显著降低,GSH-Px水平显著升高,且观察组各指标显著优于对照组,差异有统计学意义(P<0.05);2组不良反应发生情况比较无统计学意义(P>0.05)。结论α-硫酸锌联合神经妥乐平治疗Ⅱ型糖尿病合并周围神经病变疗效显著,可显著降低血清GGT、MDA水平,并提高GSH-Px水平,减轻氧化应激反应,安全性较高,值得临床推广。Objective To explore the effect of a-zinc sulfate combined with Neurotropin on serum GGT,MDA and GSH-Px levels in patients with type 2 diabetes mellitus complicated with peripheral neuropathy. Methods A total of 100 patients with type II diabetes mellitus complicated with peripheral neuropathy in our hospital were selected and randomly assigned to the observation group （50 patients） and the control group （50 patients）. The control group was treated by Neurotropin,and the observation group was treated with α-zinc sulfate on the basis of the control group, the clinical curative efficacy, serum GGT, MDA and GSH-Px lev- els and safety evaluation of the two groups was appraised. Results The clinical curative effect of observation group was signifi- cantly higher than the control group （P〈0.05）, Before treatment, there was no significant difference in serum GGT, MDA and GSH-Px levels between the two groups （P〉0.05） ,After treatment, both groups showed lower GGT and MDA levels and higher GSH-Px level than that before the treatment, respectively. However, the observation group showed significantly lower GGT and MDA levels and higher GSH-Px level than the control group （P〈0.05）. There was no difference in adverse reactions between the two groups （P 〉 0.05）. Conclusion a-zinc sulfate combined with Neurotropinin treatment of type II diabetic peripheral neuropathy has significant curative effect,which can significantly down-regulate the serum GGT and MDA level,increase GSH-Px lelvel,and reduce oxidative stress reaction. It is safety and worthy of promotion.

关 键 词：α-硫酸锌 神经妥乐平 Ⅱ型糖尿病周围神经病 氧化应激 

分 类 号：R747.9[医药卫生—神经病学与精神病学]