4种血清肿瘤标志物联合检测在乳腺癌诊断中的临床意义  

Clinical significance of combined detection of four kinds of serum tumor markers in diagnosis for breast cancer

作　　者：黄宏鑑[1] 叶芳丽[1] 欧武英[1] 

机构地区：[1]海口市人民医院检验科,海口570208

出　　处：《国际检验医学杂志》2017年第15期2060-2061,2064,共3页International Journal of Laboratory Medicine

摘　　要：目的探究血清糖类抗原(CA)125、CA153、癌胚抗原(CEA)及肿瘤特异度生长因子(TSGF)4项血清肿瘤标志物联合检测在乳腺癌诊断中的临床意义。方法将2015年3月至2016年3月在该院就诊的125例患者为研究对象,其中乳腺癌组65例,良性乳腺疾病组60例,并以55例健康体检者为对照组。检测3组研究对象血清中的CA125、CA153、CEA及TSGF等,观察并对比这4项肿瘤标志物在乳腺癌诊断中的应用价值。结果乳腺癌组患者的血清CA125、CA153、CEA及TSGF水平均明显高于良性乳腺疾病组和对照组,差异均有统计学意义(P<0.05)。同时4项血清肿瘤标志联合检测的灵敏度为90.2%,特异度为88.9%,明显高于单项血清肿瘤标志物检测的灵敏度和特异度,差异有统计学意义(χ2=26.12,P<0.05)。结论 4项血清肿瘤标志物联合检测不仅将乳腺癌诊断的灵敏度提高,同时也提高了乳腺癌诊断的特异度,为乳腺癌的诊断提供了有力的依据,值得临床推广。Objective To explore the clinical significance of combined detection of carbohydrate antigen（CA）125,CA153,carcinoembryonic antigen（CEA）and tumor specific growth factor（TSGF）in diagnosis for breast cancer.Methods A total of 125 patients with breast cancer were recruited as objects in this study from march 2015 to march 2016,65 patients in breast cancer group,60 patients in benign breast disease group,meanwhile 55 healthy person were enrolled in the control group.Serum tumor markers such as CA125,CA153,CEA and TSGF were detected and compared in the three groups.Results The serum CA125,CA153,CEA and TSGF levels in the breast cancer group were significant higher than those of benign breast disease group and healthy group,the differences were statistical significant（P〈0.05）.At the same time,the sensitivity and specificity of joint detection of four kinds of serum tumor marker were 90.2% and 88.9%,which were higher than those of single serum tumor marker detection（χ2=26.12,P〈0.05）.Conclusion The four kinds of serum tumor markers combined testing not only increases the sensitivity of breast cancer diagnosis,but also improved the specificity of diagnosis of breast cancer.

关 键 词：乳腺癌 肿瘤标志物 电化学发光法 联合检测 

分 类 号：R730.43[医药卫生—肿瘤] R737.9[医药卫生—临床医学]