有效镇痛对肝癌术后肝功能恢复的影响  

Influence of effective analgesia on liver function recovery in patients undergoing hepatectomy

作　　者：刘建军[1] 袁西景 阚和平[1] 

机构地区：[1]南方医科大学南方医院肝胆外科,广州市510515

出　　处：《实用医学杂志》2017年第15期2517-2520,共4页The Journal of Practical Medicine

基　　金：广东省自然科学基金资助项目(编号:2016A030313555)

摘　　要：目的探讨疼痛对开腹肝切除术后肝功能恢复的影响。方法收集257例行肝部分切除术且经病理诊断为原发性肝癌患者的临床病理资料,按数字等级法(NRS)分为有效镇痛组(NRS≤3分)和无效镇痛组(NRS>3分),对比分析两组术后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBi L)、白蛋白(ALB)及凝血酶原时间(PT)等肝功能指标变化情况。结果两组患者术前肝功能无差异,有效镇痛组患者术后1、3、5、7 d ALT、AST、PT、TBIL明显低于无效镇痛组(P<0.05),肝功能恢复延迟发生率低、恢复快。结论有效镇痛治疗可减轻肝癌患者术后肝功能损害、加速肝功能恢复。Objective To investigate the influence of pain on liver function recovery after hepatectomy Methods Clinical data of 257 patients with primary hepatocellular carcinoma were analyzed retrospectively.The patients were divided into effective analgesia group(NRS≤3 points)and ineffective analgesia group(NRS>3points)according to the digital hierarchy(NRS).The serum liver function indexes including ALT,AST,TBi L,ALB and PT were compared in 2 groups.Results There was no significant difference in preoperative liver function between 2 groups but the levels of ALT,AST,PT and TBIL at 1st,3rd,5th and 7th days postoperatively were lower in effective analgesia group than those in ineffective analgesic group after surgery(P<0.05).The incidence of the delay of liver function was lower in effective analgesia group than that in ineffective analgesic group.Conclusion Effective analgesic treatment can reduce liver damage and accelerate liver function recovery.

关 键 词：原发性肝癌 肝切除术 疼痛 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]