两种黏膜保护剂合并戒烟对消化性溃疡的疗效比较  

Comparison on the effect of two kinds of mucosal protective agents combined with smoking cessation on the treatment of peptic ulcer

作　　者：刘光胜 徐芳 周建勇 周胜亮[2] 

机构地区：[1]九江县人民医院消化内科,江西九江332100 [2]南昌大学第四附属医院呼吸与危重症医学科,江西南昌330003

出　　处：《中国生化药物杂志》2017年第8期88-90,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨两种黏膜保护剂合并戒烟对消化性溃疡的疗效。方法 选取2014年1月-2016年12月收治的消化性溃疡吸烟患者244例为研究对象,随机分为对照组122例给予戒烟＋奥美拉唑＋枸橼酸铋钾治疗,观察组122例患者给予戒烟＋洛赛克＋米索前列醇治疗,比较2组治疗效果及不良反应情况。结果 观察组治疗总有效率97.54%显著高于对照组87.70%,差异具有统计学意义（Ρ〈0.05）;观察组不良反应发生率2.46%显著低于对照组7.38%,差异具有统计学意义（Ρ〈0.05）。结论 对有吸烟习惯的难治性消化性溃疡的治疗,戒烟＋洛赛克＋米索前列醇治疗可有效提高临床治疗效果,且降低不良反应,是值得重视及推广的治疗方法。Objective To investigate the effect of two kinds of mucosal protective agents combined with smoking cessation on peptic ulcer. Methods In our hospital from January 2014 to December 2016, 244 cases with peptic ulcer with smoking as the research object, randomly divided into the control groupand the observation group, 122cases in each group. The control group were given omeprazole and smoking cessation and bismuth potassium citrate, the observation group were given omeprazole and smoking cessation and misoprostol. The therapeutic effect and adverse reaction were compared between the two groups. Results The total efficiency in the observation group 97.54% was significantly higher than the control group 87.70% （P〈0.05）. The incidence of adverse reactions in the observation group 2.46% was significantly lower than in the control group 7.38% （P〈0.05）. Conclusion For the treatment of refractory peptic ulcer with the habit of smoking, smoking cessation combined with Losec and misoprostol can effectively improve the effect, and reduce the occurrence of adverse reaction, which is worthy of promotion.

关 键 词：黏膜保护剂 戒烟 消化性溃疡 

分 类 号：R573.1[医药卫生—消化系统]