miR-27a-3p在高血压性脑出血患者外周血中呈下调表达  

miR-27a-3p Downregulated in Peripheral Blood of Patients with Hypertensive Intracerebral Hemorrage

作　　者：金枫[1] 唐菱[1] 王加璐[1] 朱颖[1] 何志义[1] 

机构地区：[1]中国医科大学附属第一医院神经内科,110001

出　　处：《中国临床神经科学》2017年第4期361-367,共7页Chinese Journal of Clinical Neurosciences

基　　金：国家自然科学基金面上项目(编号:81271291)

摘　　要：目的探讨脑出血患者外周血血清miR-27a-3p的表达情况。方法选取31例脑出血患者(脑出血组)和11例体检健康对照者(对照组),收集临床资料,qRT-PCR法测定外周血血清中miR-27a-3p的表达水平。结果与健康对照组比较,脑出血组血清miR-27a-3p表达呈显著下调(miR-27a-3p相对表达量为0.29),脑出血组血清miR-27a-3p表达水平与血肿体积呈明显线性负相关(相关系数R=--0.502,P=0.004)。结论在脑出血患者外周血血清miR-27a-3p表达水平呈下调趋势,其表达量与血肿体积呈线性负相关关系,可能成为脑出血患者血肿体积的预测指标。Aim To investigate the expression of miR-27a-3p in peripheral blood serum of patients with intracerebral hemorrage. Methods A total of 31 patients with intracerebral hemorrage and 11 healthy controls were enrolled in this study. Their clinical data were collected, and the expression of mi R-27a-3p in peripheral blood serum was determined by the q RT-PCR method. Result The expression of miR-27a-3p was significantly downregulated in peripheral blood serum of patients with intracerebral hemorrhage（relative expression of miR-27a-3p was 0.29）, and the expression of miR-27a-3p was negatively correlated to the hematoma volume（R= 0.502, P=0.004）. Conclusion The expression of miR-27a-3p was downregulated in peripheral blood serum of patients with intracerebral hemorrhage, and was negatively correlated to the hematoma volume. miR-27a-3p should be a promising predictor of hematoma volume in intracerebral hemorrhage.

关 键 词：miR-27a-3p 微小RNA 脑出血 外周血 表达谱 

分 类 号：R743[医药卫生—神经病学与精神病学]