Krüppel样转录因子家族在阿尔茨海默病发病机制中的作用研究进展  

The Progress of Krüppel-like Factor Family in Pathogenesis of Alzheimer's Disease

作　　者：张译丹[1] 伊然[2] 董齐[1] 张歌[1] 程雪娇[1] 关爽[1] 高青青[2] 曹海玲[1] 郑晓荣[1] 陈本伟 赵静 唐晶[5] 

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,150001 [2]哈尔滨医科大学附属第一医院内分泌科,150001 [3]陕西省安康市中心医院,725000 [4]哈尔滨市第二医院,150026 [5]吉林医药学院附属医院神经内科,132013

出　　处：《中国临床神经科学》2017年第4期458-464,480,共8页Chinese Journal of Clinical Neurosciences

基　　金：国家自然科学基金(编号:81500912);黑龙江省自然科学基金(编号:H2015059);黑龙江省青年科学基金(编号:QC2011C117)

摘　　要：阿尔茨海默病(AD)是一种中枢神经系统退行性疾病,主要病理特征是脑内β淀粉样蛋白沉积形成的老年斑和tau蛋白异常磷酸化后形成的神经纤维缠结。近年研究发现,Krüppel样转录因子在AD病理生理中扮演着不可或缺的角色,这些转录因子家族成员在细胞生长、分化、增殖、迁移、凋亡、代谢和炎症反应中具有多种调节功能。最新证据表明Krüppel样转录因子参与AD的发生发展。文中详细综述了Krüppel样转录因子家族在AD发病机制中的最新作用及其相关研究进展。Alzheimer＇s disease（AD） is a degenerative disease of the central nervous system, the main pathological features of the brain β-amyloid（Aβ） deposition formation of age spots and tau abnormal phosphorylation after the formation of nerve fiber entanglement. In recent years, Krüppellike factor plays an indispensable role in AD pathophysiology. These zinc finger transcription factor family members in cell growth, differentiation, proliferation, migration, apoptosis, metabolism andinflammation have a variety of regulatory functions. Recent evidences suggested that Krüppellike transcription factors were involved in the pathogenesis of AD. The role of the Krüppel-like transcription factor family in the pathogenesis of AD and its associated progression were reviewed.

关 键 词：阿尔茨海默病 Krüppel样转录因子 转录因子 β淀粉样蛋白 TAU蛋白 神经轴突 

分 类 号：R735.1[医药卫生—肿瘤]