基于数据挖掘中医治疗精液异常用药规律研究  

Traditional Chinese Medicine in seminal abnormality:A Medication Analysis Based on Data Mining

作　　者：张硕[1,2] 吴嘉瑞[1] 刘鑫馗 

机构地区：[1]北京中医药大学,北京100102 [2]北京市回民医院,北京100054

出　　处：《世界中医药》2017年第7期1688-1692,共5页World Chinese Medicine

基　　金：北京市中医药科技发展基金课题(JJ-2010-70);北京中医药大学与北京灸道堂中医研究院合作课题(BUCM-JDT2014001);北京市与中央在京高校共建项目(BJGJ1420)

摘　　要：目的:探讨古代药家以及全国中医药名家治疗精液异常病的用药规律。方法:搜集古代药家以及全国中医药名家治疗精液异常病处方,采用关联规则Apriori算法和复杂系统熵聚类方法,根据中医传承辅助系统软件构建数据库,确定处方中各药物和药物组合的使用频数、药物之间的关联规则、符合关联系数的药对、药物的核心组合及药物治疗精液异常病的新处方,分析精液异常病的用药经验。结果:高频药物包括枸杞子、菟丝子、熟地黄、当归、淫羊藿等;高频药物组合包括"枸杞子,菟丝子""熟地黄,枸杞子""熟地黄,菟丝子"等;置信度为0.9以上的关联规则包括"枸杞子,覆盆子→菟丝子""覆盆子→菟丝子"等。结论:古代名家以及全国名老中医药专家治疗精液异常病多用补肾益精、养阴温阳之品,配伍精巧合法,符合中医标本兼治的用药规则,对临床经验具有重要实用价值。Objective： To investigate the medication rules of ancient Chinese medical masters and the national famous Chinese medicine experts in seminal abnormality. Methods： The prescriptions for seminal abnormality were collected to build a database based on Traditional Chinese Medicine（ TCM） inheritance assist system. After analyzed with data mining,such as apriori algorithm and complex system entropy cluster,the frequency of single medicine and drug combinations that used in prescriptions and the association rules among drugs,drugs pair with correlation coefficient,core combination of drugs and new prescriptions for the treatment of abnormal semen were discussed. Results： The most frequently used drugs were Lycii Fructcs,Cuscutae Semen,Rehmanniate Radix Praeparata,Angelicae Sinensis Radix,and Epimedii Foliuml. The most frequently used drug combinations were＂Lycii Fructcs,Cuscutae Semen＂,＂Rehmanniate Radix Praeparata,Lycii Fructcs＂,＂Rehmanniate Radix Praeparata,Cuscutae Semen; And as to those the confidence of drug association rules was above 0. 9,the drug combinations were＂Lycii Fructcs,Rubi Fructus→Cuscutae Semen＂and ＂Rubi Fructus → Cuscutae Semen ＂. Conclusion： The drugs used by ancient Chinese medical masters and the national famous Chinese medicine experts in seminal abnormality were often with actions of tonifying kidney essence,nourishing yin and warming yang,with the refined compatibility and the TCM medication principles for treating symptoms and root causes,which can be used to analyze senior TCM doctor clinical experience.

关 键 词：精液异常病 名医经验 关联规则 聚类算法 

分 类 号：R256.59[医药卫生—中医内科学]