卒中后抑郁患者载脂蛋白H与认知功能的相关性  

Correlation of apolipoprotein H and cognitive function in post-stroke depression patients

作　　者：李静[1] 郑振雨[2] 王静[3] 宋景贵[4] 

机构地区：[1]新乡医学院第三附属医院神经内一科,河南新乡453003 [2]新乡医学院第三附属医院骨科,河南新乡453003 [3]新乡医学院第三附属医院心脏病监护病房,河南新乡453003 [4]新乡医学院第一附属医院神经内科,河南新乡453100

出　　处：《新乡医学院学报》2017年第8期719-722,共4页Journal of Xinxiang Medical University

基　　金：河南省卫生厅医学科技攻关基金资助项目(编号:20080308);新乡医学院高学历资助项目(编号:08BSSKYQD-003)

摘　　要：目的观察卒中后抑郁(PSD)患者载脂蛋白H(ApoH)水平和认知功能障碍的相关性。方法选择2010年1月至2015年12月新乡医学院第三附属医院收治的脑卒中患者188例,根据是否伴有卒中后抑郁将患者分为PSD组(n=92)和单纯脑卒中组(n=96);另选取90名健康志愿者作为对照组。采用聚合酶链式反应检测ApoH mRNA的表达量,酶联免疫吸附试验检测Apo H蛋白水平,采用事件相关电位(ERPs)来评定患者的认知功能。结果 3组研究对象N_1、P_2潜伏期比较差异均无统计学意义(P>0.05)。PSD组患者N_2及P_3潜伏期长于对照组和单纯脑卒中组,P_3波幅低于对照组和单纯脑卒中组(P<0.05);单纯脑卒中组和对照组受试者N_2、P_3潜伏期,P_3波幅比较差异均无统计学意义(P>0.05)。PSD组、单纯脑卒中组和对照组受试者ApoH mRNA表达量分别为0.89±0.16、0.76±0.14、0.67±0.14。PSD组患者ApoH mRNA表达量高于单纯脑卒中组和对照组(P<0.05);单纯脑卒中组患者ApoH mRNA表达量高于对照组(P<0.05)。PSD组、单纯脑卒中组和对照组受试者ApoH蛋白水平分别为(0.98±0.13)、(0.79±0.23)、(0.61±0.33)g·L^(-1)。PSD组患者Apo H蛋白水平高于单纯脑卒中组和对照组(P<0.05);单纯脑卒中组患者ApoH蛋白水平高于对照组(P<0.05)。PSD组患者血清ApoH蛋白水平与N_2、P_3潜伏期成正相关(P<0.05);其余指标之间无相关性(P>0.05)。结论 PSD患者认知功能障碍与ApoH蛋白存在相关性。Objective To investigate the correlation of apolipoprotein H （ApoH） levels and cognitive dysfunction in patients with post-stroke depression （PSD）.Methods One hundred and eighty-eighty patients with stroke were selected in the Third Affiliated Hospital of Xinxiang Medical University from January 2010 to December 2015.The patients were divided into PSD group （n =92） and stroke group （n =96） according to whether patients with post-stroke depression;ninety healthy volunteers were selected as control group.The expression of ApoH mRNA was detected by polymerase chain reaction;the level of ApoH protein was detected by enzyme linked immunosorbent assay;the cognitive function of patients was evaluated by eventrelated potential.Results There was no significant difference in the latency of N1 and P2 among the three groups （P 〉 0.05）.The latency of N2,P3 of patients in the PSD group were longer than those in the control group and stroke group;but the amplitude of P3 in the PSD group was lower than that in the control group and stroke group （P 〈 0.05）.There was no significant difference in the latency of N2,P3,the amplitude of P3 between the stroke group and control group（P 〉 0.05）.The expression level of ApoH mRNA in PSD group,stroke group and control group was 0.89 ±0.16,0.76 ±0.14 and 0.67 ±0.14 respectively;the expression level of ApoH mRNA in PSD group was significantly higher than that in the stroke group and control group （P 〈 0.05）;the expression level of ApoH mRNA in stroke group was significantly higher than that in the control group （P 〈 0.05）.The concentration of ApoH protein in PSD group,stroke group and control group was （0.98 ± 0.13）,（0.79 ± 0.23）,（0.61 ±0.33）g ＆#183; L-1 respectively;the concentration of ApoH protein in PSD group was significantly higher than that in the stroke group and control group（P 〈 0.05）;the concentration of ApoH protein in stroke group was significantly higher than that in the control group（P 〈0.05）.The seru

关 键 词：卒中后抑郁 载脂蛋白H 认知功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]