乙酰肝素酶在白血病细胞中的表达  

Expression of heparanase protein in leukemia cells

作　　者：云雁[1] 张冬霞[1] 李志芹[1] 贾国荣[1] 刘学文[1] 白学琴[1] 韩轩茂[1] YUN Yan ZHANG Dongxia LI Zhiqin JIA Guorong LIU Xuewen BAI Xueqin HAN Xuanrnao(Department of Hematology, the First Affiliated Hospital, Baotou Medical College, Baotou, 014010, China)

机构地区：[1]包头医学院第一附属医院血液科,内蒙古包头014010

出　　处：《临床血液学杂志》2017年第4期535-537,共3页Journal of Clinical Hematology

摘　　要：目的:观察乙酰肝素酶(HPA)在不同类型白血病细胞中的表达。方法:研究组为白血病患者53例,对照组为缺铁性贫血患者20例。采用Western blotting方法检测骨髓单个核细胞HPA蛋白表达,比较研究组与对照组、研究组内急性髓系白血病与急性淋巴细胞白血病、初发急性白血病与慢性白血病HPA蛋白表达差异。结果:研究组患者骨髓中单个核细胞HPA蛋白表达与对照组比较均显著升高(均P<0.05)。研究组内比较,急性髓系白血病HPA蛋白表达显著高于急性淋巴细胞白血病(P<0.05);初发急性白血病骨髓中单个核细胞HPA蛋白表达显著高于慢性白血病组(P<0.05)。结论:白血病细胞HPA蛋白高表达;不同类型白血病表达水平不同,急性白血病,尤其是急性髓系白血病表达更加明显。Objective：To explore the expression of heparanase（HPA）protein in leukemia cells.Method：The study group included 53 patients with leukemia and the control group included 20 patients with iron deficiency anemia.The expression of HPA protein in mononuclear cells of bone marrow was detected by Western blotting to compare the difference of HPA protein between the leukemia group and the control group,between the acute myeloid leukemia and the acute lymphocytic leukemia,between the primary acute leukemia and the chronic leukemia respectively.Result：The expression of HPA protein in leukemia group was higher than that in the control group（P〈0.05）.The expression of HPA protein in patients with acute myeloid leukemia was higher than that in patients with acute lymphocytic leukemia（P〈0.05）.The expression of HPA protein in patients with newly diagnosed acute leukemia was higher than that in patients with chronic leukemia（P〈0.05）.Conclusion：The expression of HPA protein is high in the leukemia cells.It is different in various types of leukemia,and the expression in acute leukemia,particularly in acute myeloid leukemia,is more obvious.

关 键 词：乙酰肝素酶 白血病 细胞 

分 类 号：R733.7[医药卫生—肿瘤]