单体核型急性髓系白血病特征及预后  

Features and prognosis of acute myeloid leukemia with monosomal karyotype

作　　者：梅迪[1,2] 刘辉[3] 

机构地区：[1]北京医院国家老年医学中心,北京100730 [2]北京大学医学部第五临床医学院 [3]北京医院国家老年医学中心血液科

出　　处：《临床血液学杂志》2017年第4期560-563,共4页Journal of Clinical Hematology

摘　　要：Breems等回顾性研究了733例不伴核心结合因子细胞遗传学异常的急性髓系白血病（acute myeloid leukemia,AML）患者（15-60岁）,发现伴有单体核型（monosomal karyotype,MK）的AML患者（MK-AML）完全缓解率低,总体生存率低,复发率高,且预后极差,4年总体生存率仅为4%,MK较复杂核型（complex karyotype,CK）更能提示AML预后不佳,从而提出了MK概念。Monosomal karyotype has recently been reported to identify a distinct subset of acute myeloid leukemia（AML）with adverse prognosis.Patients with monosomal karyotype have unique clinical features and biological characteristics.The incidence of monosomal karyotype-AML increases with the age of patients.The most common single autosomal monosomy is the loss of chromosome 7which is followed by the loss of chromosome 5.Patients with monosomal karyotype-AML have significantly worse overall survival,disease-free survival,and complete response compared with the patients with other unfavorable karyotypes.Monosomal karyotype is an independent prognostic factor for patients with AML receiving chemotherapy and allogeneic hematopoietic stem cell transplantation.New agents and treatment regimen need to be investigated.

关 键 词：白血病 髓系 急性 单体核型 特征 预后 

分 类 号：R773.71[医药卫生—眼科]