头颈部肿瘤术后放疗后淋巴水肿发生的影响因素  

Risk factors of lymphoedema following postoperative radiation for head and neck tumors

作　　者：吴海霞[1] 傅燕[2] 鞠进[1] Wu Haixia Fu Yan Ju Jin(Department of Oncology,The First Affiliated Hospital of Chongqing Medical University, Chonqqing 400016, China Ophthalmology Department, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China)

机构地区：[1]重庆医科大学附属第一医院肿瘤科,重庆400016 [2]重庆市中医院眼科,重庆400021

出　　处：《实用肿瘤杂志》2017年第4期329-331,共3页Journal of Practical Oncology

摘　　要：目的探讨头颈部肿瘤患者术后放疗后淋巴水肿发生的影响因素。方法收集接受术后放疗的128例头颈部肿瘤患者,随访1年~2年7个月。回顾性分析年龄、性别、颈部淋巴结清扫术、放疗剂量、同步化疗、放射性皮炎以及预防性使用改善微循环药物与放疗后淋巴水肿的关系。结果颈部淋巴结清扫术、放疗剂量和预防性使用改善微循环药物是影响淋巴水肿发生的重要因素(均P<0.05)。结论接受颈部淋巴结清扫术以及术后放疗剂量60Gy的头颈部肿瘤患者发生局部淋巴水肿的风险较高,而预防性使用改善微循环药物可以有效预防水肿的发生。Objective To analyze the risk factors of lymphoedema following postoperative radiation in patients with head and neck tumors. Methods One-hundred-and-twenty-eight patients with head and neck tumors undergoing postoperative radiation were enrolled,and followed up for 12 to 31 months. The association of factors,including age,gender,neck lymph node dissection,radiotherapy dose,synchronous chemotherapy,radioactive dermatitis and the preventive usage of microcirculation drugs,with the development of lymphoedema after radiotherapy were analyzed. Results Neck lymph node dissection,radiotherapy dose,and the not using microcirculation drugs were independent risk factors of lymphoedema（ all P〈0. 05）. Conclusions Head and neck tumor patients who have received neck lymph node dissection and/or postoperative radiation therapy with a dosage of 60 Gy have higher risk of developing lymphoedema. Preventive usage of microcirculation drugs can effectively prevent the occurrence of lymphoedema.

关 键 词：头颈部肿瘤/放射疗法 颈淋巴结清扫术 手术后期间 水肿/并发症 水肿/治疗 微循环/药物作用 地奥司明/药理学 七叶素/药理学 

分 类 号：R739.91[医药卫生—肿瘤] R730.55[医药卫生—临床医学]