外周血中CEA和CA19-9的表达水平在进展期胃癌中的预后价值  

Prognostic value of CEA and CA19-9 expression in peripheral blood of patients with advanced gastric cancer

作　　者：张锡[1] 陈力[2] 薛英威[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院外科,哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院胃肠外科

出　　处：《实用肿瘤学杂志》2017年第4期342-347,共6页Practical Oncology Journal

摘　　要：目的探讨外周血中CEA和CA19-9的表达水平在进展期胃癌中的预后价值及进展期胃癌患者预后的影响因素。方法选取2010年1月—2010年12月于哈尔滨医科大学附属肿瘤医院胃肠外科行R0根治术的进展期胃癌患者255例,根据CEA和CA19-9的表达水平分为A组(CEA<2.19 ng/mL且CA19-9<10.78 U/mL)、B组(CEA≥2.19 ng/mL或CA19-9≥10.78 U/mL)和C组(CEA≥2.19 ng/mL且CA19-9≥10.78 U/mL),比较三组进展期胃癌患者的临床病理资料和生存情况,并分析进展期胃癌患者预后的影响因素。结果三组进展期胃癌患者间临床N分期、临床TNM分期和病理TNM分期的差异均具有统计学意义(P<0.05),三组进展期胃癌患者术后中位生存时间差异无统计学意义(P>0.05);术后1年、3年、5年生存率差异无统计学意义(P>0.05),但A组1年、3年、5年生存率高于B组和C组。影响胃癌预后的因素包括肿瘤分化程度、病理T分期、病理TNM分期、清扫淋巴结总数、清扫淋巴结阳性数、淋巴结转移情况。结论 CEA和CA19-9联合检测对进展期胃癌患者评估预后有一定的参考价值。Objective The aims of this study were to investigate the prognostic value of CEA and CA19-9 expression in advanced gastric cancer and the prognostic factors of advanced gastric cancer.Methods A total of 255 patients with advanced gastric cancer who underwent radical R0 radical surgery were enrolled in the Department of Gastrointestinal Surgery,Harbin Medical University Cancer Hospital from January 2010 to December 2010,and were divided into group A（CEA〈2.19ng/mL and CA19-9〈10.78U/mL）,group B（CEA≥2.19ng/mL or CA19-9≥10.78U/mL）and group C（CEA≥2.19ng/mL and CA19-9≥10.78U/mL）.These groups were analyzed the differences in gastric cancer patients with clinical pathology and survival,and prognostic factors of patients with advanced gastric cancer factors.Results There were statistically significant differences in clinical N staging,clinical TNM staging and pathological TNM staging in three groups of patients with advanced gastric cancer（P〈0.05）.There was no significant difference in the median survival time in three groups of patients with advanced gastric cancer（P〉0.05）.The 1-year,3-year and 5-year survival rates of group A were higher than those of group B and group C（P〉0.05）.The factors affecting the prognosis of gastric cancer included the degree of tumor differentiation,pathological T staging,pathological TNM staging,the total number of lymph nodes,the number of positive lymph nodes and lymph node metastasis.Conclusion Combined detection of CEA and CA19-9 expression indicates a certain reference value for prognosis of gastric cancer.

关 键 词：进展期胃癌 CEA CA19-9 总生存时间 

分 类 号：R735.2[医药卫生—肿瘤]