1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的神经生物学功能研究进展  

Research progress of neurobiological function of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline

作　　者：郑晓彤[1] 陈薛钗[1] 陈姿喧[2] 庆宏[2] 邓玉林[2] 钟儒刚[1] 郭敏军[1] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124 [2]北京理工大学生命科学与技术学院,北京100081

出　　处：《生物医学工程学杂志》2017年第4期643-647,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金青年基金(81400935)

摘　　要：1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉(Sal)是一种儿茶酚异喹啉类物质,主要存在于哺乳动物脑内并执行多种生理功能。通过机体代谢,Sal可转变成为内源性神经毒素参与帕金森病(PD)的发生,由此引发学者的广泛关注。近年的研究显示,Sal还参与酒精成瘾的形成以及影响神经内分泌系统相关激素的释放,是潜在的多巴胺能神经元调节因子。本文从以上几方面展开探讨Sal的神经生物学功能,为深入研究其具体作用机制提供理论支持。1-methy1-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline （Sal） is a kind of catechol isoquinoline compound, which mainly exists in mammalian brain and performs a variety of biological functions. Through in vivo metabolism, Sal can be transformed into endogenous neurotoxins and can participate the occurrence of Parkinson＇s disease （PD）. This has attracted widespread concern of researchers. Recently, many research works have shown that Sal may lead to alcohol addiction and regulate hormone release of the neuroendocrine system, which indicated that it is a potential regulator of dopaminergic neurons. In this paper, we discuss the neural functions of Sal on the above aspects, and wish to provide some theoretical supports for further research on its mechanism.

关 键 词：1-甲基-6 7-二羟基-1 2 3 4-四氢异喹啉 帕金森病 酒精成瘾 神经调节 多巴胺 

分 类 号：R742.5[医药卫生—神经病学与精神病学]