Ubiquilin1蛋白在乳腺癌组织中的表达与预后意义  

Expression of Ubiquilin1 Protein in Breast Cancer Tissues and Its Prognostic Significance

作　　者：付慧[1] 李艳萍[1] 汪云超[2] 赵霞[1] 冯宇[1] 吕淑贞[1] 王丹丹[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院乳腺科,北京100038 [2]首都医科大学友谊医院干部医疗科,北京100050

出　　处：《肿瘤防治研究》2017年第8期535-539,共5页Cancer Research on Prevention and Treatment

摘　　要：目的探讨Ubiquilin1蛋白(UBQLN1)在乳腺癌中的表达及预后意义。方法应用免疫组织化学方法检测108例乳腺癌标本中UBQLN1的表达,并分析其与临床病理学特征、复发转移及生存时间的关系。结果 UBQLN1在乳腺癌中阳性表达率为50.9%(55/108),其表达与肿瘤大小、TNM分期、淋巴结转移个数、脉管浸润、神经侵犯、Ki-67、P53、肿瘤远处转移呈正相关(P<0.05),而与年龄、绝经状态、病理类型、组织学分级、ER、PR、HER2/neu表达、基因分型、淋巴浆细胞浸润等无明显相关性(P>0.05)。Spearman秩相关检验得出UBQLN1表达与P53的表达呈正相关(r=0.262,P=0.006)。Kaplan-Meier单因素生存分析结果显示,UBQLN1表达程度与患者的生存率明显负相关(P<0.05)。Cox多因素回归分析证明UBQLN1是乳腺癌总生存期(overall survival,OS)和无病生存期(disease free survival,DFS)的独立预后因子。结论 UBQLN1在乳腺癌中相对高表达,并与多种临床病理学特征相关,且与患者不良预后密切相关,可能作为乳腺癌患者的一项预后预测指标。Objective To investigate the expression of Ubiquilinl（UBQLN1） protein in breast cancer tissues and its prognostic significance. Methods Immunohistochemistry for UBQLN1 expression was performed on 108 cases of breast cancer specimens. Additionally, the relationship between UBQLN1 expression and clinicopathological features, recurrence, metastasis, survival time was analyzed. Results The positive expression rate of UBQLN1 in breast cancer tissues was 50.9%（55/108） and positively associated with tumor size, TNM stage, number of lymph node metastasis, vascular invasion, perineural invasion, Ki-67, P53 and distant metastasis（P〈0.05）. There was no correlation between UBQLN1 expression and age, menostasis, pathological type, pathological grade, ER, PR, Her2/neu, genetic typing or lymphoplasmacytic invasion （P〉0.05）. Non-parametric Spearman rank correlation analysis showed that there was a positive correlation between the expression of UBQLN1 and P53 （r=0.262, P=-0.006）. Univariate Kaplan-Meier analyses revealed there was negative correlation between the overexpression of UBQLNI and survival rate （P〈0.05）. Coxregression analysis indicated that the overexpression of UBQLN1 was an independent prognostic factor for overall survival （OS） and disease free survival （DFS） of breast cancer patients. Conclusion UBQLN1 is overexpressed in breast cancer samples and closely associated with various clinicopathological features and poor prognosis of breast cancer patients. It could be a novel molecular marker to evaluate the prognosis of breast cancer patients.

关 键 词：乳腺癌 UBQLN1 预后 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]