宫颈癌在超声造影检查中的影像特征及其与ki67抗原的相关性研究  

作　　者：杨成梁[1] 毛连梅 何小红 魏丽美 唐小鸳 林海棠 

机构地区：[1]浙江省嘉兴市第二医院,314000 [2]武警总队浙江杭州医院,310016

出　　处：《浙江临床医学》2017年第9期1604-1605,1608,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨宫颈癌在超声造影检查中的影像特征及其与ki67抗原的相关性。方法选取2015年1月至2016年3月确诊为宫颈癌而行手术治疗的患者40例（所有患者均得到术后病理学检查证实），均在手术前接受超声造影检查并获得峰值强度（PI）、显影时间（AT）及达峰时间（TTP）等超声造影参数，并与术后组织标本进行免疫组化检查所获的细胞核增殖抗原（ki67抗原）表达情况作比较分析。结果宫颈癌组织的AT和TTP较正常宫颈组织呈现明显减少，差异有统计学意义（P〈0．05）；宫颈癌组织PI较正常宫颈组织呈现明显增大，差异有统计学意义（P〈0．05）；ki67阳性宫颈癌组织中增强不匀、灌注缺损的出现率较ki67阴性宫颈癌组织增大，差异有统计学意义（P〈0．05）；ki67阳性宫颈癌组织的AT和TTP较ki67阴性宫颈癌组织明显减少，差异有统计学意义（P〈0．05）；ki67阳性宫颈癌组织的PI较ki67阴性宫颈癌组织明显增大，差异有统计学意义（P〈0．05）。结论宫颈癌在超声造影检查中有特征性的形态学改变，并与ki67抗原的表达情况存在一定关系，可为宫颈癌的临床诊疗及预后提供参考依据。Objective To explore the features of cervical cancer in contrast-enhanced ultrasound （ CEU ） and its correlation with nuclear proliferation antigen （ ki67 antigen ） . Methods A total of 40 cases （ confirmed by postoperative pathology ） who had the surgical treatment in patients with cervical cancer were selected during 2015-1 to 2016-3 in our hospital, preoperatively accepted CEU and got peak intensity （ PI ） , arrival time （ AT ） and time to peak （ TTP ） , compared with ki67 antigen expression of postoperative tissue samples got by immunohistochemical examination. Results AT and TTP in cervical cancer tissue reduced obviously than those in normal cervical tissue （ P〈0.05 ） ; Pi in cervical cancer tissue increased obviously than that in normal cervical tissues （ P〈0,05 ） . The emergence rate of uneven enhancement, perfusion defect in Ki67 positive cervical cancer tissue increased obviously than those in the ki67 negative cervical cancer tissue （ P〈0.05 ） ; AT and TTP in Ki67 positive cervical cancer ki67 decreased significantly than those in negative cervical cancer tissue （ P〈0.05 ） ; P] in Ki67 positive cervical cancer tissue increased obviously than that in ki67 negative cervical cancer tissue （ P〈0.05 ） . Conclusion Cervical cancer has the characteristic morphological changes in CEU, and there is a certain relationship with ki67 antigen expression, can provide reference for the clinical diagnosis, treatment and prognosis of cervical cancer.

关 键 词：宫颈癌 超声造影 病理 细胞核增殖抗原 诊断 

分 类 号：R739.41[医药卫生—肿瘤]