郁乐疏合剂治疗帕金森病伴发抑郁的临床疗效  

Clinical Effects of YuLeShu Mixture in Treating the Depression of the Patients with Parkinson′s Disease

作　　者：冉宁晶[1] 杨芳[1] 陈卫银[1] 杨东东[1] RAN Ningjing YANG Fang CHEN Weiyin YANG Dongdong(Neurology Department of Teaching Hospital of Chengdu University of TCM, Chengdu 610075, China)

机构地区：[1]成都中医药大学附属医院神经内科,四川成都610075

出　　处：《西部中医药》2017年第7期89-93,共5页Western Journal of Traditional Chinese Medicine

基　　金：成都中医药大学附属医院科技发展基金(编号2011-D-YY-17)

摘　　要：目的:观察郁乐疏合剂治疗帕金森病伴发抑郁的临床疗效。方法:将帕金森病合并抑郁症患者68例随机分为治疗组35例和对照组33例,对照组给予常规抗帕金森病药物治疗,治疗组在对照组治疗的基础上口服郁乐疏合剂3个月。评价2组患者治疗前后统一帕金森病评分量表(UPDRS)、汉密顿抑郁量表(HAMD)以及帕金森病的非运动性症状问卷(NMSQest)评分,同时观察2组疗效并监测用药安全性。结果:2组患者治疗前UPDRS、HAMD及NMSQest评分比较差异无统计学意义(P>0.05),用药6周后2组评分均有所下降,治疗组HAMD评分下降明显,与对照组比较差异有统计学意义(P<0.05);治疗12周后,治疗组评分和治疗前以及对照组之间比较差异均有统计学意义(P<0.05),对照组3种评分和治疗前比较差异无统计学意义(P>0.05)。治疗组对于抑郁及非运动症状的总有效率分别为60.0%(21/35)和57.1%(20/35),均明显高于对照组的9.1%和9.1%,差异有统计学意义(P<0.05)。结论:郁乐疏合剂能改善帕金森病伴发抑郁患者非运动症状,疗效较好且安全。Objective： To observe clinical effects of YuLeShu mixture in treating Parkinson＇s disease （PD） complicated with depression. Methods： All 68 PD patients were randomized into 35 cases of the treatment group and 33 cases of the control group, the control group accepted conventional treatment of anti-PD drug, the treatment group took YuLeShu mixture orally for three months on the foundation of the treatment the control group accepted. Unified Parkinson＇s disease rating scales （UPDRS）, Hamilton depression rating scale （HAMD） and non motor symptom questionnaire （NMSQest） of PD in both groups were assessed before and after treating, clinical effects of both groups were observed and the safety of drug use were monitored. Results： The difference had statistical meaning in the comparison of UPDRS scales and HAMD scales and NMSQest before treating between both groups （P〉0.05）, the scales of both groups decreased after medicating for six weeks, HAMD scales of the treatment group decreased obviously, and the difference showed statistical meaning compared with the control group （P〈0.05）; the difference had statistical meaning when the scales of the treatment group after treating were compared with these before treating and the control group after treating for 12 weeks （P〈0.05）, the difference had no statistical meaning when three scales of the control group after treating were compared with these before treating （P〉0.05）. Total effective rates of the treatment group to depression and non motor symptom were 60.0% （21/35） and 57.1% （20/35） respectively, obviously higher than 9.1% and 9.1% of the control group, and the difference had statistical meaning （P〈0.05）. Conclusion： YuLeShu mixture is effective and safe in treating PD complicated with depression, it could improve non motor symptom of the patients.

关 键 词：帕金森病 抑郁 非运动症状 郁乐疏合剂 

分 类 号：R742[医药卫生—神经病学与精神病学]