帕金森病患者血尿酸和25-羟维生素D_3水平的观察研究  

Serum uric acid and 25 hydroxyl vitamin D_3 levels in Parkinson's disease patients

作　　者：王丽君[1] 郭永涛[1] 尚进[1] 孙成梅[1] 郭建一[1] 程谦涛[1] 胡伟[2] WANG Li-jun GUO Yong-tao SHANG Jin et al(Department of Neurology ,Affiliated Huai＇an First People＇s Hospital of Nanjing Medical University, Huai＇an 223300 ,Jiangsu Province ,Chin)

机构地区：[1]南京医科大学附属淮安第一医院神经内科,223300 [2]淮安市疾病预防控制中心

出　　处：《中华老年心脑血管病杂志》2017年第8期806-808,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨血尿酸和25-羟维生素D3与帕金森病的关系。方法选取2014年8月~2016年8月在南京医科大学附属淮安第一医院神经内科住院的帕金森病患者106例(帕金森病组),并选择同期体检中心健康体检者104例(对照组)。收集所有参加者年龄、性别、血尿酸、血清25-羟维生素D3等基线资料,并进行组间比较。结果帕金森病组血尿酸和25羟维生素D3水平明显低于对照组[(263.24±105.02)μmol/L vs(304.11±79.31)μmol/L,P=0.002;(27.14±6.45)μg/L vs(36.96±11.62)μg/L,P=0.001]。logistic回归分析显示,年龄(OR=1.024,95%CI:1.001~1.081,P=0.028)、血尿酸(OR=0.996,95%CI:0.992~1.000,P=0.001)、25-羟维生素D3(OR=0.890,95%CI:0.852~0.929,P=0.000)与帕金森病显著相关。结论帕金森病患者血尿酸、血清25-羟维生素D3水平显著降低,高水平的血尿酸、血清25-羟维生素D3很可能是帕金森病保护因素。Objective To study the relationship of serum uric acid（UA）and 25hydroxyl（OH）vitamin D3 levels with Parkinson＇s disease（PD）.Methods One hundred and six PD patients admitted to our hospital from August 2014 to August 2016 served as a PD group and 108 healthy persons undergoing physical examination served as a control group in this study.Their baseline data（including age,gender,serum UA and 25 OH vitamin D3 levels）were recorded and compared.Results The serum UA and 25 OH vitamin D3 levels were significantly lower in PD group than in control group（263.24±105.02μmol/Lvs 304.11±79.31μmol/L,P=0.002;27.14±6.45μg/Lvs36.96±11.62μg/L,P=0.001）.Logistic regression analysis showed that age and serum levels of UA and 25 OH vitamin D3 were closely related with PD（OR=1.024,95%CI：1.001-1.081,P=0.028;OR=0.996,95%CI：0.992-1.000,P=0.001;OR=0.890,95%CI：0.852-0.929,P=0.000）.Conclusion The serum UA and 25 OH vitamin D3 levels are significantly lower in PD patients,high UA and 25 OH vitamin D3 levels are thus a protective factor for PD.

关 键 词：帕金森病 尿酸 骨化二醇 氧化性应激 

分 类 号：R742.5[医药卫生—神经病学与精神病学]